THE EFFECT OF MATERNAL HYPOTHYROIDISM DURING PREGNANCY ON CARBOHYDRATE METABOLISM IN ADULTHOOD IN RATS

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ZAHEDIASL S.; FARAAHANI H.; GHASEMI ASGHAR; FARAJI SHAHRIVAR F.

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Journal: Physiology and Pharmacology Year:2009 | Volume:12 | Issue:4 Page(s): 261-267

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Title

THE EFFECT OF MATERNAL HYPOTHYROIDISM DURING PREGNANCY ON CARBOHYDRATE METABOLISM IN ADULTHOOD IN RATS

Author(s)

ZAHEDIASL S. | FARAAHANI H. | GHASEMI ASGHAR | FARAJI SHAHRIVAR F. | Issue Writer Certificate

Keywords

MATERNAL HYPOTHYROIDISMQ3

CARBOHYDRATE METABOLISMQ3

INTRAVENOUS GLUCOSE TOLERANCE TESTQ3

ADULTHOODQ3

INSULINQ3

RATQ3

Abstract

Introduction: Many of the diseases of ADULTHOOD are originated from the intrauterine conditions during fetal life. Because of the importance of thyroid hormones in growth and development of the fetus, the effects of MATERNAL HYPOTHYROIDISM on CARBOHYDRATE METABOLISM in ADULTHOOD were investigated.Methods: Pregnant RATs were divided into the fetal hypothyroidism (FH) and the control (C) groups. During the gestational period, propylthiouracil (PTU) dissolved in drinking water (100 ppm) was administered to the FH group, while the C group drank tap water. After delivery and maturation of male neonates, INTRAVENOUS GLUCOSE TOLERANCE TEST (IVGTT) was performed. For IVGTT tests, catheters were inserted into the femoral vein and artery after anesthesia. The first arterial sample was taken before injections, then the glucose solution was injected and other samples were obtained after 5, 10, 15, 20, 30 and 60 minutes. Plasma glucose and INSULIN concentrations were measured using the glucose oxidase and an ELISA method, respectively.Results: Plasma glucose concentration 5 min after glucose injection in the FH group (239.2±15.6 mg/dL) was significantly higher than the C group (190.1±4.5 mg/dL, P<0.05). There was no significant difference in plasma INSULIN concentrations of the 2 groups. Daily water consumption during the gestation in PTU administered mothers was significantly lower compared to the C group (P<0.05). The body weight of animals was significantly (P<0.05) lower in the FH group compared with the C group.Conclusion: MATERNAL HYPOTHYROIDISM can alter CARBOHYDRATE METABOLISM during ADULTHOOD, which may contribute to the development of diabetes.

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References

EFFECT OF ORAL ADMINISTRATION OF PROPYLTHIOURACIL DURING PREGNANCY AND LACTATION IN FEMALE RATS ON ISOLATED AORTA RESPONSE IN THEIR ADULT MALE OFF SPRINGS

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APA: Copy

ZAHEDIASL, S., FARAAHANI, H., GHASEMI, ASGHAR, & FARAJI SHAHRIVAR, F.. (2009). THE EFFECT OF MATERNAL HYPOTHYROIDISM DURING PREGNANCY ON CARBOHYDRATE METABOLISM IN ADULTHOOD IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(4), 261-267. SID. https://sid.ir/paper/75120/en

Vancouver: Copy

ZAHEDIASL S., FARAAHANI H., GHASEMI ASGHAR, FARAJI SHAHRIVAR F.. THE EFFECT OF MATERNAL HYPOTHYROIDISM DURING PREGNANCY ON CARBOHYDRATE METABOLISM IN ADULTHOOD IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2009;12(4):261-267. Available from: https://sid.ir/paper/75120/en

IEEE: Copy

S. ZAHEDIASL, H. FARAAHANI, ASGHAR GHASEMI, and F. FARAJI SHAHRIVAR, “THE EFFECT OF MATERNAL HYPOTHYROIDISM DURING PREGNANCY ON CARBOHYDRATE METABOLISM IN ADULTHOOD IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 4, pp. 261–267, 2009, [Online]. Available: https://sid.ir/paper/75120/en

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