Evaluation of the effect of oral cyclophosphamide in the treatment of children with refractory idiopathic nephrotic syndrome over a period of 20 years

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ABBASI ARASH

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Journal Paper

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Journal: Iranian Journal of Kidney Diseases Year:2020 | Volume:14 | Issue:5 Page(s): 1-4

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Title

Evaluation of the effect of oral cyclophosphamide in the treatment of children with refractory idiopathic nephrotic syndrome over a period of 20 years

Author(s)

ABBASI ARASH | Issue Writer Certificate

Keywords

steroid resistance nephrotic syndrome

Cyclophosphamide

remission

Abstract

Introduction. Nephrotic syndrome (NS) is the most common chronic kidney disease in children. Most patients have a benign clinical course and respond well to steroids. Patients who do not respond to steroids are steroid resistance nephrotic syndrome (SRNS), and there is disagreement about the treatment of these patients. Cyclophosphamide (CP) has been used in the treatment of SNRS, but its effectiveness has been questioned. The aim of this study was to evaluate the drug response and side effects of CP in the treatment of SRNS in the Children’ s Medical Center Hospital. Material and methods. This study was performed as a case series. In this study, idiopathic SRNS patients over one year of age who did not enter remission after daily prednisolone (PDN) treatment and used oral CP in the later stages of their treatment were included in the study. All patients were followed up with CBC and regular visits to control drug side effects. Cases whose information was distorted or incomplete excluded. Results. In this study, 52 SRNS patients with a mean age of 5. 3 ± 5. 3 years were studied, of whom 24 (46%) were male and 22 (54%) were female. The follow-up period of patients was 1-264 months. In this study, 38. 5% of patients were sensitive to CP and 61. 5% of patients were resistant to CP. The response to CP was not significantly different between the ages of higher 6 years and under. (p = 0. 655) There was no significant relationship between remission rate and type of pathology and CP addition to treatment. But there was a significant difference between ESRD and CP resistance. Conclusion. From the results of this study, it can be concluded that Cyclophosphamide has no significant effect on the remission of SNRS patients, but has made a significant difference in the development of ESRD in patients.

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APA: Copy

ABBASI, ARASH. (2020). Evaluation of the effect of oral cyclophosphamide in the treatment of children with refractory idiopathic nephrotic syndrome over a period of 20 years. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 14(5), 1-4. SID. https://sid.ir/paper/751330/en

Vancouver: Copy

ABBASI ARASH. Evaluation of the effect of oral cyclophosphamide in the treatment of children with refractory idiopathic nephrotic syndrome over a period of 20 years. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2020;14(5):1-4. Available from: https://sid.ir/paper/751330/en

IEEE: Copy

ARASH ABBASI, “Evaluation of the effect of oral cyclophosphamide in the treatment of children with refractory idiopathic nephrotic syndrome over a period of 20 years,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 14, no. 5, pp. 1–4, 2020, [Online]. Available: https://sid.ir/paper/751330/en

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