ASSESSMENT OF THE EFFECT OF NITRIC OXIDE WITHIN HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN MORPHINE DEPENDENT RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

POURMOTEABED A.R.; YAGHMAEI PARICHEHR; IMANI PARVIZ; NEDAEI S.E.; TOUHIDI ATEFEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2008 | Volume:11 | Issue:4 Page(s): 252-260

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,027

Download:

Cites:

Information Journal Paper

Title

ASSESSMENT OF THE EFFECT OF NITRIC OXIDE WITHIN HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN MORPHINE DEPENDENT RATS

Author(s)

Keywords

NITRIC OXIDEQ3

MORPHINEQ3

HIPPOCAMPAL CA1Q3

SPATIAL LEARNING AND MEMORYQ3

RATQ3

Abstract

Introduction: There are evidences showing the role of NITRIC OXIDE in the opiate reward properties. The role of NITRIC OXIDE signaling pathway as an intracellular mechanism on augmentation of long term potentiation in HIPPOCAMPAL CA1 area of RATs is also confirmed. It has been also reported that oral MORPHINE dependence facilitates formation of SPATIAL LEARNING AND MEMORY via activation of NMDA receptors located in HIPPOCAMPAL CA1 area of RATs. The effect of NITRIC OXIDE within HIPPOCAMPAL CA1 area on the SPATIAL LEARNING AND MEMORY processes in MORPHINE dependent RATs is unclear.Methods: 33 N-MRI male RATs (250-350 g) were divided into 4 experimental groups. Two cannulae were stereotaxically implanted bilaterally into HIPPOCAMPAL CA1 area. After 5 days recovery, animals received MORPHINE sulfate or sucrose for 30 consecutive days in drinking water. Morris water maze (MWM) studies were performed from day 26 to 30. In this period animals received bilateral intra-hippocampal CA1 injection of 3mg/ 2ml L-NAME (NOS inhibitor) or 2ml saline (1ml/site), 1 min before daily experimentation. SPATIAL LEARNING AND MEMORY parameters were subjected to analysis of variance (ANOVA).Results: MORPHINE dependence facilitated SPATIAL LEARNING AND MEMORY in RATs. This effect was inhibited with local administration of L-NAME in HIPPOCAMPAL CA1 area.Conclusion: Activation of intracellular NO signaling pathway in the pyramidal cells of HIPPOCAMPAL CA1 area may involve in facilitating SPATIAL LEARNING AND MEMORY in MORPHINE dependent RATs.

Cites

No record.

References

Cite

APA: Copy

POURMOTEABED, A.R., YAGHMAEI, PARICHEHR, IMANI, PARVIZ, NEDAEI, S.E., & TOUHIDI, ATEFEH. (2008). ASSESSMENT OF THE EFFECT OF NITRIC OXIDE WITHIN HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN MORPHINE DEPENDENT RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(4), 252-260. SID. https://sid.ir/paper/75143/en

Vancouver: Copy

POURMOTEABED A.R., YAGHMAEI PARICHEHR, IMANI PARVIZ, NEDAEI S.E., TOUHIDI ATEFEH. ASSESSMENT OF THE EFFECT OF NITRIC OXIDE WITHIN HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN MORPHINE DEPENDENT RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;11(4):252-260. Available from: https://sid.ir/paper/75143/en

IEEE: Copy

A.R. POURMOTEABED, PARICHEHR YAGHMAEI, PARVIZ IMANI, S.E. NEDAEI, and ATEFEH TOUHIDI, “ASSESSMENT OF THE EFFECT OF NITRIC OXIDE WITHIN HIPPOCAMPAL CA1 AREA ON SPATIAL LEARNING AND MEMORY IN MORPHINE DEPENDENT RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 4, pp. 252–260, 2008, [Online]. Available: https://sid.ir/paper/75143/en

Related Journal Papers