THE EFFECT OF DEXTROMETHORPHAN ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK

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FARZIN D.

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Journal: Physiology and Pharmacology Year:2003 | Volume:7 | Issue:1 Page(s): 47-56

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Title

THE EFFECT OF DEXTROMETHORPHAN ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK

Author(s)

FARZIN D. | Issue Writer Certificate

Keywords

STEREOTYPED BEHAVIORQ4

PECKINGQ4

DEXTROMETHORPHANQ4

NMDA RECEPTORSQ3

CHICKQ3

Abstract

Dextromethorphan is a NMDA receptor antagonist in the glutamatergic system. Currently, there are some reports showing that the glutamatergic NMDA receptor mechanism stimulates dopamine release from several brain regions. This effect may in part modulate the STEREOTYPED BEHAVIORs of dopaminergic system. The purpose of the present study was to determine the interaction between the blockade of NMDA receptor and the stereotyped PECKING behavior in CHICKs. DEXTROMETHORPHAN was used for the blockade of NMDA RECEPTORS. In the present study, the effects of DEXTROMETHORPHAN and different dopamine receptor antagonists on apomorphine-induced PECKING behavior were examined. For the induction of PECKING, apomorphine (ED53) at a dose of 0.5 mg/kg (s.c.) was used. The results showed that DEXTROMETHORPHAN (5-15 mg/kg, s.c.) in a dose-dependent pattern reduce the PECKING behavior. Subcutaneous injection of DEXTROMETHORPHAN (5 mg/kg, EDso) did not alter the suppressive action of the dopamine DJ receptor antagonist SCH 23390 (1-4 mg/kg, s.c.), but potentiated the suppressive action of the dopamine Dz receptor antagonist sulpiride (10-30 mg/kg, s.c.). The peripheral dopamine receptor antagonist domperidone (5 and 10 mg/kg, s.c.) elicited no significant effect. These results suggested that the central dopamine Dl receptor mechanism in part mediates the suppressive action of DEXTROMETHORPHAN on apomorphine-induced PECKING behavior.

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APA: Copy

FARZIN, D.. (2003). THE EFFECT OF DEXTROMETHORPHAN ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK. PHYSIOLOGY AND PHARMACOLOGY, 7(1), 47-56. SID. https://sid.ir/paper/75169/en

Vancouver: Copy

FARZIN D.. THE EFFECT OF DEXTROMETHORPHAN ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;7(1):47-56. Available from: https://sid.ir/paper/75169/en

IEEE: Copy

D. FARZIN, “THE EFFECT OF DEXTROMETHORPHAN ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN CHICK,” PHYSIOLOGY AND PHARMACOLOGY, vol. 7, no. 1, pp. 47–56, 2003, [Online]. Available: https://sid.ir/paper/75169/en

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