ROLE OF NITRIC OXIDE ON THE ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED RABBIT ATRIOVENTRICULAR NODE BY EXTRACELLULAR FIELD POTENTIAL DURING ATRIAL FIBRILLATION

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KHORI VAHID; ALIZADEH ALI MOHAMMAD; NAVAEIAN AMENEH; NAYEBPOUR MOHSEN; POURABOUK MONA; BADAGHABADI FAKHRI; CHANGIZI SHIMA; RAJAEI MARYAM; MOHEIMANI HAMIDREZA; YAZDI HAMIDREZA; SALEKI SAEED

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:3 Page(s): 295-307

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Title

ROLE OF NITRIC OXIDE ON THE ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED RABBIT ATRIOVENTRICULAR NODE BY EXTRACELLULAR FIELD POTENTIAL DURING ATRIAL FIBRILLATION

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Keywords

NITRIC OXIDEQ3

AV NODEQ2

ELECTROPHYSIOLOGYQ2

CONCEALED CONDUCTIONQ2

ATRIAL FIBRILLATIONQ2

Abstract

Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit.Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concentrations of L-argenine (250 mM-5000 mM) were added to the solution. Programmed stimulation protocols were used to quantify AV nodal conduction time, refractoriness and zone of concealment. AF protocol was executed by software with coupling intervals (ranging from 75-125 msec).Results: L-NAME had depressive effects on basic AV nodal properties. L-Arginine (250mM) had direct inhibitory effects on nodal conduction time, Wenckebach and refractoriness. Significant increases in the number of concealed beats were induced by L-Arginine (500 mM ). Number of concealed beats were increased from 700.7±33.7 to 763±21 msec (P<0.05). Trend of zone of concealment prolongation in a frequency-dependent model was abrogated by Larginine (250, 5000 mM).Conclusion: NO at low concentration (in the presence of L-NAME) had facilitatory role on AV nodal properties, but at high concentration (in the presence of L-arginine) enhanced protective role of AV NODE during AF. Biphasic modulatory role of NO may affect protective behavior of AV NODE during AF.

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APA: Copy

KHORI, VAHID, ALIZADEH, ALI MOHAMMAD, NAVAEIAN, AMENEH, NAYEBPOUR, MOHSEN, POURABOUK, MONA, BADAGHABADI, FAKHRI, CHANGIZI, SHIMA, RAJAEI, MARYAM, MOHEIMANI, HAMIDREZA, YAZDI, HAMIDREZA, & SALEKI, SAEED. (2011). ROLE OF NITRIC OXIDE ON THE ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED RABBIT ATRIOVENTRICULAR NODE BY EXTRACELLULAR FIELD POTENTIAL DURING ATRIAL FIBRILLATION. PHYSIOLOGY AND PHARMACOLOGY, 15(3), 295-307. SID. https://sid.ir/paper/75174/en

Vancouver: Copy

KHORI VAHID, ALIZADEH ALI MOHAMMAD, NAVAEIAN AMENEH, NAYEBPOUR MOHSEN, POURABOUK MONA, BADAGHABADI FAKHRI, CHANGIZI SHIMA, RAJAEI MARYAM, MOHEIMANI HAMIDREZA, YAZDI HAMIDREZA, SALEKI SAEED. ROLE OF NITRIC OXIDE ON THE ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED RABBIT ATRIOVENTRICULAR NODE BY EXTRACELLULAR FIELD POTENTIAL DURING ATRIAL FIBRILLATION. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(3):295-307. Available from: https://sid.ir/paper/75174/en

IEEE: Copy

VAHID KHORI, ALI MOHAMMAD ALIZADEH, AMENEH NAVAEIAN, MOHSEN NAYEBPOUR, MONA POURABOUK, FAKHRI BADAGHABADI, SHIMA CHANGIZI, MARYAM RAJAEI, HAMIDREZA MOHEIMANI, HAMIDREZA YAZDI, and SAEED SALEKI, “ROLE OF NITRIC OXIDE ON THE ELECTROPHYSIOLOGICAL PROPERTIES OF ISOLATED RABBIT ATRIOVENTRICULAR NODE BY EXTRACELLULAR FIELD POTENTIAL DURING ATRIAL FIBRILLATION,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 3, pp. 295–307, 2011, [Online]. Available: https://sid.ir/paper/75174/en

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