EVALUATION OF THE EFFECT OF TAURINE ON CISPLATIN-INDUCED HEPATIC INJURY AND OXIDATIVE STRESS IN MALE RATS

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NOROZI MARYAM; ZARE SAMAD

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:3 Page(s): 427-434

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Title

EVALUATION OF THE EFFECT OF TAURINE ON CISPLATIN-INDUCED HEPATIC INJURY AND OXIDATIVE STRESS IN MALE RATS

Author(s)

NOROZI MARYAM | ZARE SAMAD | Issue Writer Certificate

Keywords

CISPLATINQ3

TAURINEQ2

HEPATIC INJURYQ3

ANTIOXIDANTQ3

Abstract

Introduction: The principal dose-limiting factor in the use of CISPLATIN as an antineoplastic drug is its hepatic toxicity. This study was designed to investigate the protective role of TAURINE against CISPLATIN-induced HEPATIC INJURY.Methods: Male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): CISPLATIN-treated group (10 mg/kg ip) (3): group that received TAURINE (200 mg/kg ip) for 1hr before CISPLATIN (10 mg/kg ip) administration (4): TAURINE treated group (200 mg/kg ip). After 7 days, the animals were sacrificed and blood samples collected from the heart as well as liver tissues were kept at -70oC till further analyses.Results: analyses showed that CISPLATIN significantly increased ALT and AST serum levels (P<0.05) while pretreatment with TAURINE resulted in the reduction of these markers. Catalase activity in CISPLATIN-treated rats was significantly decreased (P<0.05) and TAURINE administration could recover this reduction. MDA content of the liver tissue was significantly increased in CISPLATIN-exposed animals, while TAURINE treatment reduced the amount of MDA in liver tissue.Conclusion: Our data suggest that TAURINE prevents from CISPLATIN-induced HEPATIC INJURY and this effect may be due to its ANTIOXIDANT properties.

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APA: Copy

NOROZI, MARYAM, & ZARE, SAMAD. (2011). EVALUATION OF THE EFFECT OF TAURINE ON CISPLATIN-INDUCED HEPATIC INJURY AND OXIDATIVE STRESS IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 15(3), 427-434. SID. https://sid.ir/paper/75178/en

Vancouver: Copy

NOROZI MARYAM, ZARE SAMAD. EVALUATION OF THE EFFECT OF TAURINE ON CISPLATIN-INDUCED HEPATIC INJURY AND OXIDATIVE STRESS IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(3):427-434. Available from: https://sid.ir/paper/75178/en

IEEE: Copy

MARYAM NOROZI, and SAMAD ZARE, “EVALUATION OF THE EFFECT OF TAURINE ON CISPLATIN-INDUCED HEPATIC INJURY AND OXIDATIVE STRESS IN MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 3, pp. 427–434, 2011, [Online]. Available: https://sid.ir/paper/75178/en

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