ASSESMENT OF OREXIN RECEPTOR 1 IN STRESS ATTENUATED NOCICEPTIVE BEHAVIOURS IN FORMALIN TEST

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SOFI ABADI MOHAMMAD; HEIDARI ORANJAGHI NIMA; GHASEMI ELMIRA; ESMAEILI MOHAMMAD HOSSEIN; HAGHDOOST YAZDI HASHEM; ERAMI ELAHEH; AZHDARI ZARMEHRI HASSAN

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:3 Page(s): 395-402

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Title

ASSESMENT OF OREXIN RECEPTOR 1 IN STRESS ATTENUATED NOCICEPTIVE BEHAVIOURS IN FORMALIN TEST

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Keywords

ACUTE STRESSQ3

PAINQ2

FORMALIN TESTQ3

RATQ3

OREXIN RECEPTOR 1Q2

Abstract

Introduction: It is known that acute and chronic stress induce hormonal and neuronal changes which affecting both PAIN threshold and nociceptive behaviours. Orexin plays an important role in modulation of PAIN and stress. Considering PAIN modulation during stress and the role of orexin in PAIN and stress, orexin might be involved in PAIN modulation during stress. We evaluated the involvement of orexin receptor-1in acute immobilization stress on the tonic PAIN model.Methods: Adult male, Wistar RATs (200-300 g), placed in a stereotaxic apparatus and canulla were inserted into their left cerebral ventricle. After 1 week of recovery, animals were initially submitted to one session of acute restraint stress (30 min) and immediately submitted to formalin injection in the hind paw to evaluate nociceptive behaviours. OREXIN RECEPTOR 1 antagonist (SB 334867) was injected intracerebroventricularly, 5 minute before formalin injection, while the solvent was injected in the control group.Results: two percent formalin produced typical biphasic PAIN responses in RATs that was observed for more than 1 hour. Acute exposure to restraint stress reduced the nociceptive behaviour by chemical stimulation in phase 1, interphase and phase 2. The short-term stress induced analgesia was reflected in a decrease in the nociceptive behavior during phase 1, whereas the long-term stress induced analgesia was reflected in a decrease in the nociceptive behaviours during phase 2. Pretreatment with OREXIN RECEPTOR 1 antagonist (SB 334867) attenuated the antinociceptive behavioral effect of restraint stress.Conclusion: Our results indicate that OREXIN RECEPTOR 1 antagonist attenuated antinociceptive effect of restraint stress assessed by formalin. These findings show that OREXIN RECEPTOR 1 might mediate an opioid-independent stress-induced analgesia.

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APA: Copy

SOFI ABADI, MOHAMMAD, HEIDARI ORANJAGHI, NIMA, GHASEMI, ELMIRA, ESMAEILI, MOHAMMAD HOSSEIN, HAGHDOOST YAZDI, HASHEM, ERAMI, ELAHEH, & AZHDARI ZARMEHRI, HASSAN. (2011). ASSESMENT OF OREXIN RECEPTOR 1 IN STRESS ATTENUATED NOCICEPTIVE BEHAVIOURS IN FORMALIN TEST. PHYSIOLOGY AND PHARMACOLOGY, 15(3), 395-402. SID. https://sid.ir/paper/75182/en

Vancouver: Copy

SOFI ABADI MOHAMMAD, HEIDARI ORANJAGHI NIMA, GHASEMI ELMIRA, ESMAEILI MOHAMMAD HOSSEIN, HAGHDOOST YAZDI HASHEM, ERAMI ELAHEH, AZHDARI ZARMEHRI HASSAN. ASSESMENT OF OREXIN RECEPTOR 1 IN STRESS ATTENUATED NOCICEPTIVE BEHAVIOURS IN FORMALIN TEST. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(3):395-402. Available from: https://sid.ir/paper/75182/en

IEEE: Copy

MOHAMMAD SOFI ABADI, NIMA HEIDARI ORANJAGHI, ELMIRA GHASEMI, MOHAMMAD HOSSEIN ESMAEILI, HASHEM HAGHDOOST YAZDI, ELAHEH ERAMI, and HASSAN AZHDARI ZARMEHRI, “ASSESMENT OF OREXIN RECEPTOR 1 IN STRESS ATTENUATED NOCICEPTIVE BEHAVIOURS IN FORMALIN TEST,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 3, pp. 395–402, 2011, [Online]. Available: https://sid.ir/paper/75182/en

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