SCREENING OF THE ANTICONVULSANT POTENTIAL OF SOME COMMON MEDICINAL PLANTS OF IRAN IN PENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK SEIZURE MODELS IN MALE MICE

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SAYYAH MOHAMMAD; FARAJI HANIFE; DEHGHANI AGHDAS; BAKHTIARI HAMID; KAMALINEJAD MOHAMMAD; NARENJKAR JAMSHID

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:1 Page(s): 66-71

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Title

SCREENING OF THE ANTICONVULSANT POTENTIAL OF SOME COMMON MEDICINAL PLANTS OF IRAN IN PENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK SEIZURE MODELS IN MALE MICE

Author(s)

Keywords

J. REGIAQ2

C. HAUSSKNECHTIIQ3

C. ANGUSTIFOLIAQ2

A. HAMOSUSQ2

SEIZUREQ3

Abstract

Introduction: Jugulans regia (Jugulandaceae), Astragaus hamosus (Papilionaceae), Crocus pallasii subsp.haussknechtiiboiss. (Iridaceae) and Cassia angustifolia Vahl. (Caesalpinaceae) have been suggested as antiepileptic remedies in traditional medicine of Iran. The possible anticonvulsant effect of the hydroalcoholic extract of the leaves ofJ. REGIA, fruits of A. HAMOSUS, corm of C. HAUSSKNECHTII, and aerial parts of C. ANGUSTIFOLIA was evaluated in common experimental SEIZURE tests in mice.Methods: The hydroalcoholic extracts of the plants were obtained by percolation of 100g of air-dried part of each plant in 900 ml ethanol 80%. Different doses of the extracts were intraperitoneally (i.p.) administered in mice (10 male mice in each group) and occurrence of clonic SEIZUREs induced by pentylenetetrazol (PTZ; 60mg/kg, i.p.) or tonic SEIZUREs induced by maximal electroshock (MES; 50mA, 50Hz, 0.5sec) was observed 30 min thereafter. Acute toxicity of the extracts was also assessed.Results: J. REGIA, C. HAUSSKNECHTII, C. ANGUSTIFOLIA did not show any anticonvulsant activity up to the maximum safe doses of 3 g/kg, 0.25 g/kg and 2 g/kg, respectively.A. hamosus had anticonvulsant effect in PTZ test at the high and sedative dose of 6 g/kg. The extracts did not affect tonic SEIZUREs induced by MES.Conclusion: J. REGIA, C. HAUSSKNECHTII, C. ANGUSTIFOLIA and A. HAMOSUS had no anticonvulsant activity in PTZ and MES SEIZURE tests.

Cites

ANTIBACTERIAL EFFECTS ALCHOLIC EXTRACTS OF (ASTRAGALUS HAMOSUS) ON GRAM POSITIVE AND GRAM NEGATIVE BACTERIA

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APA: Copy

SAYYAH, MOHAMMAD, FARAJI, HANIFE, DEHGHANI, AGHDAS, BAKHTIARI, HAMID, KAMALINEJAD, MOHAMMAD, & NARENJKAR, JAMSHID. (2011). SCREENING OF THE ANTICONVULSANT POTENTIAL OF SOME COMMON MEDICINAL PLANTS OF IRAN IN PENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK SEIZURE MODELS IN MALE MICE. PHYSIOLOGY AND PHARMACOLOGY, 15(1), 66-71. SID. https://sid.ir/paper/75210/en

Vancouver: Copy

SAYYAH MOHAMMAD, FARAJI HANIFE, DEHGHANI AGHDAS, BAKHTIARI HAMID, KAMALINEJAD MOHAMMAD, NARENJKAR JAMSHID. SCREENING OF THE ANTICONVULSANT POTENTIAL OF SOME COMMON MEDICINAL PLANTS OF IRAN IN PENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK SEIZURE MODELS IN MALE MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(1):66-71. Available from: https://sid.ir/paper/75210/en

IEEE: Copy

MOHAMMAD SAYYAH, HANIFE FARAJI, AGHDAS DEHGHANI, HAMID BAKHTIARI, MOHAMMAD KAMALINEJAD, and JAMSHID NARENJKAR, “SCREENING OF THE ANTICONVULSANT POTENTIAL OF SOME COMMON MEDICINAL PLANTS OF IRAN IN PENTYLENETETRAZOLE AND MAXIMAL ELECTROSHOCK SEIZURE MODELS IN MALE MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 1, pp. 66–71, 2011, [Online]. Available: https://sid.ir/paper/75210/en

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