Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

254
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

98
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

3

Information Journal Paper

Title

The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome

Pages

  276-282

Abstract

 Objectives: Polycystic ovary syndrome (PCOS) has been considered as one of the most common endocrine diseases among the females in their regeneRative age with a prevalence range of 5 to 21%. However, the purpose of the present study was to investigate the protective effect of Galega Officinalis on metabolic as well as hormonal parameters in a rodent model of PCOS. Materials and Methods: Thirty-two Wistar female Rats were used (n=8/group) in the study consisting of healthy control and experimental groups. The experimental groups were divided into 3 subgroups, including Rats with PCOS which received no treatment (G1), PCOS group in which G. officinalis extract was administered daily at a dose of 200 mg/kg/orally (G2) for 2 weeks, and PCOS group in which G. officinalis extract was administered daily at a dose of 400 mg/kg/orally (G3) for 2 weeks. In all experimental groups, a single intramuscular injection of estradiol valeRate led to inducing PCOS. After the end of treatment period, Rats in all of the studied groups were anesthetized with ketamine/xylazine (5/1 mg/kg), then the blood samples obtained and their serum samples were applied for testing the fasting blood sugar (FBS), insulin, aromatase, and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and estrogen. The ovaries of Rats were removed and fixed for histopathological examinations. Results: The serum levels of FBS, insulin, LH, FSH, and testosterone significantly increased in G1 in comparison to healthy Rats (P < 0. 05), while they were all significantly decreased in the treated groups received G. officinalis extract compared to Rats affected by PCOS (P < 0. 05). Moreover, the serum level of estrogen and the serum activity of aromatase were both significantly decreased in G1 in comparison to healthy Rats (P < 0. 05), while in treated groups, they were significantly increased compared to G1 which received no treatment (P < 0. 05). Moreover, the number of follicles in ovaries affected by PCOS decreased, while both concentRations of G. officinalis extract could prevent this phenomenon. Conclusions: It seems that the extract of G. officinalis has a beneficial effect on the levels of the LH, FSH, testosterone, estradiol, aromatase, FBS, and insulin in alleviating the complications of PCOS.

Cites

References

  • No record.

    • Cite

    APA: Copy

    ABTAHI EIVARI, SEYED HOSEIN, MOGHIMIAN, MARYAM, SOLTANI, MALIHE, SHOOREI, HAMED, Asghari, Reza, Hajizadeh, Hossein, SHOKOOHI, MAJID, Alami, Somayye, & Khalife Ghaderi, Faezeh. (2018). The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 6(3), 276-282. SID. https://sid.ir/paper/752131/en

    Vancouver: Copy

    ABTAHI EIVARI SEYED HOSEIN, MOGHIMIAN MARYAM, SOLTANI MALIHE, SHOOREI HAMED, Asghari Reza, Hajizadeh Hossein, SHOKOOHI MAJID, Alami Somayye, Khalife Ghaderi Faezeh. The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES[Internet]. 2018;6(3):276-282. Available from: https://sid.ir/paper/752131/en

    IEEE: Copy

    SEYED HOSEIN ABTAHI EIVARI, MARYAM MOGHIMIAN, MALIHE SOLTANI, HAMED SHOOREI, Reza Asghari, Hossein Hajizadeh, MAJID SHOKOOHI, Somayye Alami, and Faezeh Khalife Ghaderi, “The Effect of Galega officinalis on Hormonal and Metabolic Profile in a Rat Model of Polycystic Ovary Syndrome,” INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, vol. 6, no. 3, pp. 276–282, 2018, [Online]. Available: https://sid.ir/paper/752131/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top