COMPARING THE ANALGESIC EFFECTS OF PERIAQUEDUCTAL GRAY MATTER INJECTION OF OREXIN A AND MORPHINE ON FORMALIN-INDUCED NOCICEPTIVE BEHAVIORS

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AZHDARI ZARMEHRI H.; SEMNANIAN S.; FATH ELAHI Y.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:3 Page(s): 188-193

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Information Journal Paper

Title

COMPARING THE ANALGESIC EFFECTS OF PERIAQUEDUCTAL GRAY MATTER INJECTION OF OREXIN A AND MORPHINE ON FORMALIN-INDUCED NOCICEPTIVE BEHAVIORS

Author(s)

AZHDARI ZARMEHRI H. | SEMNANIAN S. | FATH ELAHI Y. | Issue Writer Certificate

Keywords

OREXIN-AQ2

ANALGESICQ3

PERIAQUEDUCTAL GRAY MATTERQ3

FORMALIN TESTQ3

MORPHINEQ3

Abstract

Introduction: OREXIN-A and B (Hypocretin I and 2) are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus (LH). Intracisternal (ICV) and intratechal (IT) injections of OREXIN-A (hypocretin-l) have been shown to elicit ANALGESIC responses in FORMALIN TEST. However, the locations of central sites that may mediate these effects have not been clearly elucidated. Orexin-containing fibers are projected to PERIAQUEDUCTAL GRAY MATTER (PAG), which is involved in pain modulation.Methods: Behavioral study was done on male Sprague Dawley rats (200-300 g) in formalin induced nociceptive behaviour.Results: Intra-PAG microinjection of OREXIN-Aproduced a dose-dependent inhibition of formalin-evoked behavior in interphase and phase 2, but not in phase 1, indicating an antinociceptive role of exogenous OREXIN-A in the PAG. ANALGESIC effect of OREXIN-A was less than and specific to inter- and late phase of FORMALIN TEST, when compared with that of MORPHINE (5 mg/0.5ml) after intra-PAG administration.Conclusion: The obtained results suggest that OREXIN-A plays an anti-nociceptiverole in PAG, on the interphase and late phase of FORMALIN TEST in rats. So it is possible that OREXIN-A might be involved in the mechanisms of inter- and last phases of formalin induced behaviours.

Cites

OREXIN-A MODULATES FIRING OF RAT ROSTRAL VENTROMEDIAL MEDULLA NEURONS: AN IN VITRO STUDY

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APA: Copy

AZHDARI ZARMEHRI, H., SEMNANIAN, S., & FATH ELAHI, Y.. (2008). COMPARING THE ANALGESIC EFFECTS OF PERIAQUEDUCTAL GRAY MATTER INJECTION OF OREXIN A AND MORPHINE ON FORMALIN-INDUCED NOCICEPTIVE BEHAVIORS. PHYSIOLOGY AND PHARMACOLOGY, 12(3), 188-193. SID. https://sid.ir/paper/75234/en

Vancouver: Copy

AZHDARI ZARMEHRI H., SEMNANIAN S., FATH ELAHI Y.. COMPARING THE ANALGESIC EFFECTS OF PERIAQUEDUCTAL GRAY MATTER INJECTION OF OREXIN A AND MORPHINE ON FORMALIN-INDUCED NOCICEPTIVE BEHAVIORS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(3):188-193. Available from: https://sid.ir/paper/75234/en

IEEE: Copy

H. AZHDARI ZARMEHRI, S. SEMNANIAN, and Y. FATH ELAHI, “COMPARING THE ANALGESIC EFFECTS OF PERIAQUEDUCTAL GRAY MATTER INJECTION OF OREXIN A AND MORPHINE ON FORMALIN-INDUCED NOCICEPTIVE BEHAVIORS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 3, pp. 188–193, 2008, [Online]. Available: https://sid.ir/paper/75234/en

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