BEHAVIORAL STUDY OF EFFECTS OF MESENCHYMAL STEM CELLS TRANSPLANT ON MOTOR DEFICITS IMPROVEMENT IN AN ANIMAL MODEL OF HUNTINGTON'S DISEASE

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EDALATMANESH M.A.; BAHRAMI AHMAD REZA; BEHNAM RASOULI MORTEZA; MOGHIMI ALI; MOGHADAM MATIN M.; NASERI FATEMEH

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:3 Page(s): 194-200

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Title

BEHAVIORAL STUDY OF EFFECTS OF MESENCHYMAL STEM CELLS TRANSPLANT ON MOTOR DEFICITS IMPROVEMENT IN AN ANIMAL MODEL OF HUNTINGTON'S DISEASE

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Keywords

HUNTINGTON'S DISEASEQ2

MESENCHYMAL STEM CELLSQ2

CELL THERAPYQ3

DRUG INDUCED ROTATION TESTQ3

QUINOLINIC ACIDQ3

Abstract

Introduction: HUNTINGTON'S DISEASE is an inherited neurodegenerative disease associated with widespread neuronal degeneration in neostriatum and neocortex. Progress of the disease causes disabling clinical effects on movements, cognition and physiology of the body, and finally results in death. Currently, there is no effective therapeutic strategy for diminishing the motor disabilities of HUNTINGTON'S DISEASE. In recent years, cellular transplantation has been an effective therapeutic method for neurodegenerative diseases.Methods: In this study, the effects of bone marrow derived MESENCHYMAL STEM CELLS were assessed in an animal model of HUNTINGTON'S DISEASE. After causing ipsilateral lesion in the striatum with QUINOLINIC ACID, bone marrow derived MESENCHYMAL STEM CELLS which had been isolated and purified from 4-6 weeks old rats, were transplanted into the damaged striatum. The efficiency of cellular transplantation for improvement of motor disabilities was assessed by cylinder test and apomorphin induced rotation tests, during eight weeks after the transplant. Results: Results showed significant improvement (p < 0.0001) in motor disability and the percentage of striatal atrophy.Conclusion: According to these results, CELL THERAPY with bone marrow derived adult stem cells seems promising for treatment of neurodegenerative diseases, especially HUNTINGTON'S DISEASE.

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APA: Copy

EDALATMANESH, M.A., BAHRAMI, AHMAD REZA, BEHNAM RASOULI, MORTEZA, MOGHIMI, ALI, MOGHADAM MATIN, M., & NASERI, FATEMEH. (2008). BEHAVIORAL STUDY OF EFFECTS OF MESENCHYMAL STEM CELLS TRANSPLANT ON MOTOR DEFICITS IMPROVEMENT IN AN ANIMAL MODEL OF HUNTINGTON'S DISEASE. PHYSIOLOGY AND PHARMACOLOGY, 12(3), 194-200. SID. https://sid.ir/paper/75240/en

Vancouver: Copy

EDALATMANESH M.A., BAHRAMI AHMAD REZA, BEHNAM RASOULI MORTEZA, MOGHIMI ALI, MOGHADAM MATIN M., NASERI FATEMEH. BEHAVIORAL STUDY OF EFFECTS OF MESENCHYMAL STEM CELLS TRANSPLANT ON MOTOR DEFICITS IMPROVEMENT IN AN ANIMAL MODEL OF HUNTINGTON'S DISEASE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(3):194-200. Available from: https://sid.ir/paper/75240/en

IEEE: Copy

M.A. EDALATMANESH, AHMAD REZA BAHRAMI, MORTEZA BEHNAM RASOULI, ALI MOGHIMI, M. MOGHADAM MATIN, and FATEMEH NASERI, “BEHAVIORAL STUDY OF EFFECTS OF MESENCHYMAL STEM CELLS TRANSPLANT ON MOTOR DEFICITS IMPROVEMENT IN AN ANIMAL MODEL OF HUNTINGTON'S DISEASE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 3, pp. 194–200, 2008, [Online]. Available: https://sid.ir/paper/75240/en

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