EVALUATION OF TWO COLORIMETRIC METHODS FOR ACETAMINOPHEN IN UREMIA

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SAEB M.; SAJEDIANFARD J.

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Title

EVALUATION OF TWO COLORIMETRIC METHODS FOR ACETAMINOPHEN IN UREMIA

Author(s)

SAEB M. | SAJEDIANFARD J. | Issue Writer Certificate

Keywords

ACETAMINOPHENQ3

HEPATOTOXICITYQ3

RENAL FAILUREQ4

SPECTROPHOTOMETRYQ3

DRUG ASSAYQ4

Abstract

ACETAMINOPHEN, a well-known antipyretic and analgesic substitue for salicylate has been increasingly used in recent years. However, the potential for HEPATOTOXICITY and RENAL FAILURE accompanying its chronic and excessive use or its overdose in suicidal attempt necessitates a reliable, interference-free procedure for determination of ACETAMINOPHEN in serum.Various spectrophotometric methods have been established for ACETAMINOPHEN determination.Two of the common methods are Chafetz & Walberg and Indophenol. For evaluation of the two methods, different concentrations of ACETAMINOPHEN, ranging between 20 and 200 mg/L were put in the presence or absence of urea and creatinine and in addition, in normal and uremic sera. The average retrieval of ACETAMINOPHEN was 79% for sample without urea and creatinine and 86% for sample containing urea and creatinine. The difference between two retrievals was7% that indicates the interference of the materials used in the Chafetz & Walberg method. This difference was significant statistically (p=0.005, t=3.24).The retrieval of ACETAMINOPHEN in normal and uremic sera by this method were 72% and 86% respectively. Also, in this case the present difference (14%) was highly significant (p=0.0001, t=5.67), which indicates the interference of urea and creatinine and phenolic substances. The rate of ACETAMINOPHEN retrieval in the presence of mentioned compounds and in normal and uremic sera was about 89% which is not significant. Thus, urea, creatinine and uremia have no effects on ACETAMINOPHEN determination by Indophenol method. Analysis of variation coefficient of the two methods in 40mg/L and 100mg/L of ACETAMINOPHEN showed that taken together, Indophenol method is more appropriate than the Chafetz & Walberg method for ACETAMINOPHEN determination.

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APA: Copy

SAEB, M., & SAJEDIANFARD, J.. (2001). EVALUATION OF TWO COLORIMETRIC METHODS FOR ACETAMINOPHEN IN UREMIA. PHYSIOLOGY AND PHARMACOLOGY, 5(1), 87-96. SID. https://sid.ir/paper/75247/en

Vancouver: Copy

SAEB M., SAJEDIANFARD J.. EVALUATION OF TWO COLORIMETRIC METHODS FOR ACETAMINOPHEN IN UREMIA. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;5(1):87-96. Available from: https://sid.ir/paper/75247/en

IEEE: Copy

M. SAEB, and J. SAJEDIANFARD, “EVALUATION OF TWO COLORIMETRIC METHODS FOR ACETAMINOPHEN IN UREMIA,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 1, pp. 87–96, 2001, [Online]. Available: https://sid.ir/paper/75247/en

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