Predictive Power of N-terminal Prohormone of Brain Natriuretic Peptide on Admission and on Discharge for Short-and Long-term Clinical and Echocardiographic Outcomes in Patients With Pulmonary Thromboembolism

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Baradaran Abdolvahhab; KAZEMI SALEH DAVOOD; JENAB YASER; Hashemi Susan; JALALI ARASH; Feizabadi Elham

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Journal: Iranian Heart Journal Year:2020 | Volume:21 | Issue:1 Page(s): 45-54

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Title

Predictive Power of N-terminal Prohormone of Brain Natriuretic Peptide on Admission and on Discharge for Short-and Long-term Clinical and Echocardiographic Outcomes in Patients With Pulmonary Thromboembolism

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Keywords

N-terminal prohormone

Brain natriuretic peptide

Biomarkers

Pulmonary embolism

Abstract

Background: This prospective case-series study was conducted to determine the predictive power of the N-terminal prohormone of Brain natriuretic peptide (NT-proBNP) on shortand long-term outcomes in patients with pulmonary thromboembolism (PTE). Methods: Ninety-two patients (age = 60 ± 1. 97 y, 54. 7% male) diagnosed with PTE were recruited. NT-proBNP levels and echocardiographic indices were measured and recorded. The primary endpoint was considered to be 3-month PTE-related deaths and long-term adverse outcomes including 1-year all-cause mortality, rehospitalization due to the recurrence of PTE, right ventricular dysfunction, and pulmonary hypertension. Results: The serum NT-proBNP level and the right ventricular diameter were significantly higher in the patients with adverse outcomes than in the outcome-free patients. Several significant correlations were found between NT-proBNP levels and echocardiographic indices. During a mean follow-up time of 12 months, 1 patient suffered PTE relapse, 15 patients had right ventricular dysfunction and pulmonary hypertension, and 2 patients expired. Age was an independent value in the prediction of the adverse outcome (OR: 1. 064, 95% CI: 1. 01 to 1. 11). Discharge NT-proBNP levels, calculated according to a multiple cutoff point strategy for heart failure, in the PTE patients with adverse outcomes was 2. 36 fold that in the outcome-free patients. The optimal value for discharge NTproBNP according to the receiver operating characteristic analysis was 327 pg/mL, with a sensitivity of 80% and a specificity of 43%. Conclusions: NT-proBNP measurement during the course of PTE, especially on discharge, may have a role as an easy-to-use diagnostic tool for determining patients with poor prognoses.

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APA: Copy

Baradaran, Abdolvahhab, KAZEMI SALEH, DAVOOD, JENAB, YASER, Hashemi, Susan, JALALI, ARASH, & Feizabadi, Elham. (2020). Predictive Power of N-terminal Prohormone of Brain Natriuretic Peptide on Admission and on Discharge for Short-and Long-term Clinical and Echocardiographic Outcomes in Patients With Pulmonary Thromboembolism. IRANIAN HEART JOURNAL (IHJ), 21(1), 45-54. SID. https://sid.ir/paper/752507/en

Vancouver: Copy

Baradaran Abdolvahhab, KAZEMI SALEH DAVOOD, JENAB YASER, Hashemi Susan, JALALI ARASH, Feizabadi Elham. Predictive Power of N-terminal Prohormone of Brain Natriuretic Peptide on Admission and on Discharge for Short-and Long-term Clinical and Echocardiographic Outcomes in Patients With Pulmonary Thromboembolism. IRANIAN HEART JOURNAL (IHJ)[Internet]. 2020;21(1):45-54. Available from: https://sid.ir/paper/752507/en

IEEE: Copy

Abdolvahhab Baradaran, DAVOOD KAZEMI SALEH, YASER JENAB, Susan Hashemi, ARASH JALALI, and Elham Feizabadi, “Predictive Power of N-terminal Prohormone of Brain Natriuretic Peptide on Admission and on Discharge for Short-and Long-term Clinical and Echocardiographic Outcomes in Patients With Pulmonary Thromboembolism,” IRANIAN HEART JOURNAL (IHJ), vol. 21, no. 1, pp. 45–54, 2020, [Online]. Available: https://sid.ir/paper/752507/en

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