THE MODULATORY ROLE OF PROSTAGLANDINS IN VASCULAR RESPONSIVENESS TO PHENYLEPHRINE IN CHRONIC INFLAMMATION OF KNEE JOINT IN RAT

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PEZHHAN A.; HAJIZADEH S.; FATH ELAHI Y.; KHOUSHBATEN A.

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Journal: Physiology and Pharmacology Year:2001 | Volume:5 | Issue:1 Page(s): 43-54

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Title

THE MODULATORY ROLE OF PROSTAGLANDINS IN VASCULAR RESPONSIVENESS TO PHENYLEPHRINE IN CHRONIC INFLAMMATION OF KNEE JOINT IN RAT

Author(s)

PEZHHAN A. | HAJIZADEH S. | FATH ELAHI Y. | KHOUSHBATEN A. | Issue Writer Certificate

Keywords

PROSTAGLANDINQ4

KNEE JOINTQ3

CHRONIC INFLAMMATIONQ4

Α1-ADRENOCEPTORQ4

BLOOD FLOWQ4

Abstract

The role of PROSTAGLANDINs in control of joint BLOOD FLOW was investigated in chronically inflamed knee of rat. Joint inflammation was induced by intraarticular injection of Freund's Complete Adjuvant (FCA) into right KNEE JOINT and experiments were performed on the ipsilateral (right) and contralateral. (left) joints for 28 days post- treatment. BLOOD FLOW measurements of the exposed joints were made using Laser Doppler Flowmeter (LDF).Injection of FCA caused a significant increase in diameter of both ipsilateral and contralateral knees as compared with pre-injection diameter. Indomethacin (3 mg/kg, i.p.) can restore the diameter of inflamed knee to control value. Topical application of phenylephrine (10-7 to 10-3 M) in normal rats produced a dose-dependent vasoconstriction of the articular microvasculature. This constrictor response was attenuated in the ipsilateral and contralateral KNEE JOINTs of inflamed animals for 21 days, but this reduction was more obvious in contralateral knee than in ipsilateral knee and was significant as compared with control group at days 3-14. After treatment with indomethacin at days 3 and 7, vasoconstrictor response to phenylephrine increased and returned to control value in contralateral knee but had no significant effect on ipsilateral knee. At day 14, indomethacin decreased or didn't change this response in contralateral knee. These data suggest that PROSTAGLANDINs increase knee diameter in CHRONIC INFLAMMATION and these substances appear to involve in modulation of vasoconstrictor response to phenylephrine.

Cites

DOES PGE2 MEDIATEINDOMETHACIN AND THEOPHYLLINE EFFECTS ON JOINT DIAMETER AND VASCULAR RESPONSE TO SAPHENOUS NERVE STIMULATION IN CHRONICALLY INFLAMED RAT KNEE JOINT?

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APA: Copy

PEZHHAN, A., HAJIZADEH, S., FATH ELAHI, Y., & KHOUSHBATEN, A.. (2001). THE MODULATORY ROLE OF PROSTAGLANDINS IN VASCULAR RESPONSIVENESS TO PHENYLEPHRINE IN CHRONIC INFLAMMATION OF KNEE JOINT IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 5(1), 43-54. SID. https://sid.ir/paper/75253/en

Vancouver: Copy

PEZHHAN A., HAJIZADEH S., FATH ELAHI Y., KHOUSHBATEN A.. THE MODULATORY ROLE OF PROSTAGLANDINS IN VASCULAR RESPONSIVENESS TO PHENYLEPHRINE IN CHRONIC INFLAMMATION OF KNEE JOINT IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2001;5(1):43-54. Available from: https://sid.ir/paper/75253/en

IEEE: Copy

A. PEZHHAN, S. HAJIZADEH, Y. FATH ELAHI, and A. KHOUSHBATEN, “THE MODULATORY ROLE OF PROSTAGLANDINS IN VASCULAR RESPONSIVENESS TO PHENYLEPHRINE IN CHRONIC INFLAMMATION OF KNEE JOINT IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 1, pp. 43–54, 2001, [Online]. Available: https://sid.ir/paper/75253/en

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