THE ROLE OF ADENOSINE A2 RECEPTORS IN REGULATION OF PIAL VESSELS BLOOD FLOW IN ANESTHETIZED MORPHINE DEPENDENT RATS

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HOSSEINI MARZIEH; HAJIZADEH S.; FATH ELAHI Y.; GOLMOHAMMADI MOJTABA; ERFANI B.; HEYDARIANPOUR A.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:1 Page(s): 22-30

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Title

THE ROLE OF ADENOSINE A2 RECEPTORS IN REGULATION OF PIAL VESSELS BLOOD FLOW IN ANESTHETIZED MORPHINE DEPENDENT RATS

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Keywords

ADENOSINE RECEPTORSQ3

MORPHINE-DEPENDENCEQ3

PIAL VESSELS BLOOD FLOWQ3

Abstract

Introduction: Adenosine as a potent vasodilator has a physiological role in regulation of regional cerebral blood flow (rCBF).Method: Laser-Doppler flow merry technique was used to study PIAL VESSELS BLOOD FLOW responses to ADENOSINE RECEPTORS agonists and antagonist. Male Sprague Dawley rats (250-350 g) that were housed in standard conditions were anesthetized with Urethane (1.5 g/kg). Adenosine (general agonist), NECA (A2A and A2B receptor agonist) and CGS- 21380 (A2A selective agonist), were used in absence and presence of A2A receptors selective antagonist, ZM-243185, in naive and morphine-dependent rats.Results: Adenosine, NECA and CGS-21680 increased PIAL VESSELS BLOOD FLOW in naive and dependent rats dose dependently. These responses were blocked significantly by ZM-243185. Responses of pial vessels to adenosine (10-4, 10-5 and 10-6M) and NECA (10-4, 10-5 and 10-6M) were increased significantly in morphine- dependent rats in comparison to naive rats. Pial vessels responses to CGS-21680 did not show any significant differences between morphine dependent and naive rats.Conclusion: Based on these results it could be concluded that the role of A2B receptors in regulation of rCBF in morphine dependent rats is more effective than A2 Areceptors.

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APA: Copy

HOSSEINI, MARZIEH, HAJIZADEH, S., FATH ELAHI, Y., GOLMOHAMMADI, MOJTABA, ERFANI, B., & HEYDARIANPOUR, A.. (2008). THE ROLE OF ADENOSINE A₂ RECEPTORS IN REGULATION OF PIAL VESSELS BLOOD FLOW IN ANESTHETIZED MORPHINE DEPENDENT RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(1), 22-30. SID. https://sid.ir/paper/75257/en

Vancouver: Copy

HOSSEINI MARZIEH, HAJIZADEH S., FATH ELAHI Y., GOLMOHAMMADI MOJTABA, ERFANI B., HEYDARIANPOUR A.. THE ROLE OF ADENOSINE A₂ RECEPTORS IN REGULATION OF PIAL VESSELS BLOOD FLOW IN ANESTHETIZED MORPHINE DEPENDENT RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(1):22-30. Available from: https://sid.ir/paper/75257/en

IEEE: Copy

MARZIEH HOSSEINI, S. HAJIZADEH, Y. FATH ELAHI, MOJTABA GOLMOHAMMADI, B. ERFANI, and A. HEYDARIANPOUR, “THE ROLE OF ADENOSINE A₂ RECEPTORS IN REGULATION OF PIAL VESSELS BLOOD FLOW IN ANESTHETIZED MORPHINE DEPENDENT RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 1, pp. 22–30, 2008, [Online]. Available: https://sid.ir/paper/75257/en

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