THE EFFECT OF HUMULUS LUPULUS L. EXTRACT ON THE HORMONAL SYSTEM OF HYPOPHYSEAL-GONADAL AXIS IN MALE MICE

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KHAKPOUR SH.; ORYAN SHAHRBANOU; HAERI ROUHANI SEYED ALI; AMIN GH.; YAHYAVI S.H.

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Journal: Physiology and Pharmacology Year:2004 | Volume:8 | Issue:1 Page(s): 31-38

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Title

THE EFFECT OF HUMULUS LUPULUS L. EXTRACT ON THE HORMONAL SYSTEM OF HYPOPHYSEAL-GONADAL AXIS IN MALE MICE

Author(s)

Keywords

HUMULUS LUPULUS L.Q4

LD50Q3

FSHQ3

LHQ4

TESTOSTERONEQ3

MICEQ4

Abstract

Considering the widespread application of medicinal plants for the treatment of human illnesses with lower side effects in comparison with currently used medicines, this filed has been the subject of many research studies around the world. This study was conducted to evaluate the possible effect of HUMULUS LUPULUS L. hydroalcoholic extract on the hormonal system of hypophyseal-gonadal axis of adult male Balb/C MICE (250 g). After extract preparation, its lethal dose was determined as 1800 mg/Kg. Thereafter the effective doses 80, 180, 280, 380, and 480 mg/Kg were used in this study. The extract was administered intraperitoneally once a day for one month. The control group received no treatment. After the last injection of the extract, serum samples were obtained for hormone assay of hypophyseal-gonadal axis.The results showed that only the levels of LH and TESTOSTERONE in this axis significantly decrease with no significant change for FSH. This reduction can be attributed to the presence of some phytoestrogenic compounds in the extract including 8-prenylnaringenine. In this respect, it may be claimed that long-term administration of the extract increases the plasma level of. estrogen and in this way affect the performance of hypophyseal-gonadal axis. In addition, the extract could reduce the release of LH from adenohypophysis through a negative feedback mechanism, and in this way may lead to reduced release of TESTOSTERONE from testis.

Cites

STUDY OF NETTLE HYDRO ALCOHOLIC EXTRACTION (URTICA DIOICA) INFLUENCE ON SPERMATOGENESIS AND TESTOSTERONE, SPERMATOGENESIS HORMONES, CHANGES IN RATS

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APA: Copy

KHAKPOUR, SH., ORYAN, SHAHRBANOU, HAERI ROUHANI, SEYED ALI, AMIN, GH., & YAHYAVI, S.H.. (2004). THE EFFECT OF HUMULUS LUPULUS L. EXTRACT ON THE HORMONAL SYSTEM OF HYPOPHYSEAL-GONADAL AXIS IN MALE MICE. PHYSIOLOGY AND PHARMACOLOGY, 8(1), 31-38. SID. https://sid.ir/paper/75274/en

Vancouver: Copy

KHAKPOUR SH., ORYAN SHAHRBANOU, HAERI ROUHANI SEYED ALI, AMIN GH., YAHYAVI S.H.. THE EFFECT OF HUMULUS LUPULUS L. EXTRACT ON THE HORMONAL SYSTEM OF HYPOPHYSEAL-GONADAL AXIS IN MALE MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2004;8(1):31-38. Available from: https://sid.ir/paper/75274/en

IEEE: Copy

SH. KHAKPOUR, SHAHRBANOU ORYAN, SEYED ALI HAERI ROUHANI, GH. AMIN, and S.H. YAHYAVI, “THE EFFECT OF HUMULUS LUPULUS L. EXTRACT ON THE HORMONAL SYSTEM OF HYPOPHYSEAL-GONADAL AXIS IN MALE MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 8, no. 1, pp. 31–38, 2004, [Online]. Available: https://sid.ir/paper/75274/en

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