ACUTE EFFECT OF BURN TRAUMA TO SMALL SKIN AREAS ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RAT

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SHEKARFOROUSH SHAHNAZ; NOROOZZADEH ALI; SAFARI FATEMEH; GOLMANESH LEILA; KHOSHBATEN ALI

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:2 Page(s): 242-248

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Title

ACUTE EFFECT OF BURN TRAUMA TO SMALL SKIN AREAS ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RAT

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Keywords

BURNQ3

ISCHEMIAQ3

INFARCT SIZEQ2

ARRHYTHMIAQ3

Abstract

Introduction: It has been reported that traumas such as transverse abdominal incision before myocardial ISCHEMIA result in a significantly decreased INFARCT SIZE. This phenomenon is named remote preconditioning of trauma. Since small skin BURN is one of most common traumas, the effect of this injury on ISCHEMIA-induced ARRHYTHMIAs and infarctsize was investigated in a rat model of ISCHEMIA-reperfusion injury.Methods: Twenty-four male Wistar rats were randomly assigned to 3 groups. In BURN and sham groups, less than 1% of total body surface area of the dorsal skin was exposed to 100oC and 37oC water, respectively. In ischemic preconditioning group, rats were exposed to one cycle of ISCHEMIA (5 min) and reperfusion (10 min). ISCHEMIAreperfusion injury was induced with occlusion and release of left coronary artery for 30 and 120 min, respectively. INFARCT SIZE was measured using triphenyl tetrazolium chloride staining and ARRHYTHMIAs were assessed in accordancewith Lambeth conventions.Results: INFARCT SIZE was significantly reduced in ischemic preconditioning group compared with the sham group (27±2% vs. 50±5%; P<0.01). INFARCT SIZE in the BURN group was not significantly reduced. Irreversible ventricular fibrillation was 50% of all ventricular fibrillation in the BURN group, while it was 25% in the sham group; however, this difference was not significant.Conclusion: Acute minor coetaneous BURN has neither protective nor harmful for the rat myocardial ISCHEMIAreperfusion injury.

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APA: Copy

SHEKARFOROUSH, SHAHNAZ, NOROOZZADEH, ALI, SAFARI, FATEMEH, GOLMANESH, LEILA, & KHOSHBATEN, ALI. (2011). ACUTE EFFECT OF BURN TRAUMA TO SMALL SKIN AREAS ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RAT. PHYSIOLOGY AND PHARMACOLOGY, 15(2), 242-248. SID. https://sid.ir/paper/75298/en

Vancouver: Copy

SHEKARFOROUSH SHAHNAZ, NOROOZZADEH ALI, SAFARI FATEMEH, GOLMANESH LEILA, KHOSHBATEN ALI. ACUTE EFFECT OF BURN TRAUMA TO SMALL SKIN AREAS ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RAT. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(2):242-248. Available from: https://sid.ir/paper/75298/en

IEEE: Copy

SHAHNAZ SHEKARFOROUSH, ALI NOROOZZADEH, FATEMEH SAFARI, LEILA GOLMANESH, and ALI KHOSHBATEN, “ACUTE EFFECT OF BURN TRAUMA TO SMALL SKIN AREAS ON MYOCARDIAL ISCHEMIA-REPERFUSION INJURY IN RAT,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 2, pp. 242–248, 2011, [Online]. Available: https://sid.ir/paper/75298/en

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