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Information Journal Paper

Title

Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography

Pages

  14-18

Abstract

 Introduction: Data suggest that brain natriuretic peptide (BNP) and NT pro-BNP partially reflect ventricular pressure and could have a role in the early detection of diastolic abnormalities in hypertensive patients with normal systolic function. This study aimed to assess the role of NT pro-BNP for early detection of diastolic dysfunction in patients with Hypertension and to correlate its level with echocardiographic parameters of diastolic dysfunction. Methods: This is a comparative cross-sectional study. Hundred cases of asymptomatic hypertensive patients with normal left ventricular (LV) systolic function and 100 healthy subjects were subjected to Echocardiography and measurement of serum NT-pro BNP who received care at outpatient department of internal medicine, B. P. Koirala Institute of health sciences, Nepal. Results: Both systolic and diastolic blood pressures were significantly higher (≥ 160 and/or 100 mm Hg) in cases compared to controls (<120/80 mm Hg). Echocardiographic parameters of diastolic dysfunction: E/A ratio, E/E’ ratio, deceleration time and isovolumetric relaxation time showed a significant difference between cases and controls. Mean Serum NT-proBNP was significantly higher in patients with Hypertension (213. 19 ± 184. 3 pg/mL) compared to controls (58. 51 ± 11. 01 pg/mL) (P = 0. 008). There was no significant difference in mean serum NT-pro BNP levels between cases with no LV diastolic dysfunction (n=14) and controls (n=100) but it showed a significant difference between cases with LV diastolic dysfunction of all grades (n=86) and controls (n=100) (P = 0. 00). NT-proBNP levels were higher in both group of patients with E/A ratios <0. 9 and 0. 9-1. 5 (245. 72 ± 166. 73 pg/mL and 210. 69 + 143. 53 pg/mL respectively) as compared to controls. Mean Serum NT-proBNP levels were significantly higher in patients with IVRT >90 ms (270. 43 ± 180. 81 pg/mL) as compared to controls (P = 0. 03) but the difference was not significant between cases with IVRT of 60-90 ms (152. 02 ± 100. 23 pg/mL) and controls (P = 0. 09). NT-proBNP levels were significantly higher in all groups of patients with E/E’ ratios <8, 8-12, >12 (197 ± 121. 25 pg/mL, 263. 12 ± 122. 52 pg/mL and 180 ± 106. 56 pg/mL respectively) compared to controls. Conclusion: Mean Serum NT-proBNP was significantly higher in patients with Hypertension as compared to controls. There is some correlation between echocardiographic parameters of diastolic dysfunction and Serum NT-proBNP. Hence, NT-proBNP may be useful for early detection of LV diastolic dysfunction in patients with Hypertension.

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    APA: Copy

    Dhungana, Sahadeb Prasad, Karki, Prahlad, & Lamsal, Madhab. (2019). Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 11(1), 14-18. SID. https://sid.ir/paper/753079/en

    Vancouver: Copy

    Dhungana Sahadeb Prasad, Karki Prahlad, Lamsal Madhab. Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2019;11(1):14-18. Available from: https://sid.ir/paper/753079/en

    IEEE: Copy

    Sahadeb Prasad Dhungana, Prahlad Karki, and Madhab Lamsal, “Utility of N-terminal pro-brain natriuretic peptide in detecting diastolic dysfunction in asymptomatic hypertensive patients: comparison with echocardiography,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 11, no. 1, pp. 14–18, 2019, [Online]. Available: https://sid.ir/paper/753079/en

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