EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ZIZIPHUS JUJUBA ON THE PERIPHERAL BLOOD CELLS IN BALB/C MICE

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NOORI AHMAD ABADI MOSAYEB; HODJATI MOHAMMAD REZA; SEDIGHI MEHRNOOSH

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Journal: Physiology and Pharmacology Year:2013 | Volume:17 | Issue:2 Page(s): 225-230

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Title

EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ZIZIPHUS JUJUBA ON THE PERIPHERAL BLOOD CELLS IN BALB/C MICE

Author(s)

NOORI AHMAD ABADI MOSAYEB | HODJATI MOHAMMAD REZA | SEDIGHI MEHRNOOSH | Issue Writer Certificate

Keywords

ZIZIPHUS JUJUBAQ3

EXTRACTQ1

PERIPHERAL BLOOD CELLSQ2

MICEQ3

Abstract

Introduction: In the Iranian traditional medicine, ZIZIPHUS JUJUBA is recommended for treatment of anemia, but no investigation has addressed this issue. In the present study, the effect of hydro-alcoholic EXTRACT of this plant was evaluated on the PERIPHERAL BLOOD CELLS in male Balb/c MICE.Methods: Hydro-alcoholic EXTRACT was prepared from the fruits of the ZIZIPHUS JUJUBA. Male MICE were injected with normal saline or the EXTRACT (100, 200 or 400 mg/kg, i.p.) for a period of two weeks. Afterwards, the MICE were anesthetized and blood samples were taken from their hearts and then the peripheral blood was evaluated by a Cell Counter apparatus. White blood cells differential analysis was manually performed under a microscope. Data was statistically analyzed using One-way ANOVA followed by Tukey post-hoc test.Results: ZIZIPHUS JUJUBA EXTRACTs (100 and 400 mg/kg) caused a significant reduction in the percentages of monocytes and neutrophils, respectively (P<0.05). At a dose of 400 mg/kg, ZIZIPHUS JUJUBA EXTRACT increased the percentage of lymphocytes (P<0.05). However, no significant changes were observed in the amounts of WBC, RBC, platelets, hemoglobin, Hct, MCV, MCH and MCHC in the EXTRACT-treated groups (P>0.05).Conclusion: Findings of this study show that ZIZIPHUS JUJUBA EXTRACT increases the percentage of lymphocytes and also reduces the percentage of monocytes and neutrophils.

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APA: Copy

NOORI AHMAD ABADI, MOSAYEB, HODJATI, MOHAMMAD REZA, & SEDIGHI, MEHRNOOSH. (2013). EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ZIZIPHUS JUJUBA ON THE PERIPHERAL BLOOD CELLS IN BALB/C MICE. PHYSIOLOGY AND PHARMACOLOGY, 17(2), 225-230. SID. https://sid.ir/paper/75315/en

Vancouver: Copy

NOORI AHMAD ABADI MOSAYEB, HODJATI MOHAMMAD REZA, SEDIGHI MEHRNOOSH. EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ZIZIPHUS JUJUBA ON THE PERIPHERAL BLOOD CELLS IN BALB/C MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2013;17(2):225-230. Available from: https://sid.ir/paper/75315/en

IEEE: Copy

MOSAYEB NOORI AHMAD ABADI, MOHAMMAD REZA HODJATI, and MEHRNOOSH SEDIGHI, “EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF ZIZIPHUS JUJUBA ON THE PERIPHERAL BLOOD CELLS IN BALB/C MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 17, no. 2, pp. 225–230, 2013, [Online]. Available: https://sid.ir/paper/75315/en

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