STUDY OF THE CORRELATION BETWEEN ACE GENE POLYMORPHISM AND CORONARY ARTERY DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAADAT H.A.; ZIAI S.A.; NASRI S.; SAKENSHAFT M.; ANSARIAN A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2010 | Volume:13 | Issue:4 Page(s): 362-370

Download Full-Text

Persian Verion

View:

2,716

Download:

Cites:

Information Journal Paper

Title

STUDY OF THE CORRELATION BETWEEN ACE GENE POLYMORPHISM AND CORONARY ARTERY DISEASE

Author(s)

Keywords

ANGIOTENSIN CONVERTING ENZYMEQ3

CORONARY ARTERY DISEASEQ3

CADQ3

INSERTION / DELETION POLYMORPHISMQ3

Abstract

Introduction: ANGIOTENSIN CONVERTING ENZYME (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with CORONARY ARTERY DISEASE (CAD) and normal subjects. The correlation of these parameters with important CAD risk factors were also evaluated.Methods: 204 subjects were assigned to patients and normal groups based on their angiography results. Serum ACE activities were assayed by HPLC and I/D polymorphism were analyzed by PCR method. Important risk factors such as diabetes mellitus, hypertension, lipid profiles, ejection fraction, smoking and opium consumption were also recorded. Results: CAD was higher in DD genotype subjects (OR= 2.45; CI= 1.05-5.73), and ACE activity was about twice in DD compared to II genotypes. ACE activity was higher in hypertensives and diabetics in CAD group (p<0.001), but in the normal group it did not have any correlation with these risk factors. The rate of opium use was higher in ID and DD subjects.Conclusion: DD genotype is a risk factor for CAD and ACE activity is higher in this genotype. However, there is not any correlation between ACE activity and CAD.

Cites

No record.

References

No record.

Cite

APA: Copy

SAADAT, H.A., ZIAI, S.A., NASRI, S., SAKENSHAFT, M., & ANSARIAN, A.. (2010). STUDY OF THE CORRELATION BETWEEN ACE GENE POLYMORPHISM AND CORONARY ARTERY DISEASE. PHYSIOLOGY AND PHARMACOLOGY, 13(4), 362-370. SID. https://sid.ir/paper/75325/en

Vancouver: Copy

SAADAT H.A., ZIAI S.A., NASRI S., SAKENSHAFT M., ANSARIAN A.. STUDY OF THE CORRELATION BETWEEN ACE GENE POLYMORPHISM AND CORONARY ARTERY DISEASE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2010;13(4):362-370. Available from: https://sid.ir/paper/75325/en

IEEE: Copy

H.A. SAADAT, S.A. ZIAI, S. NASRI, M. SAKENSHAFT, and A. ANSARIAN, “STUDY OF THE CORRELATION BETWEEN ACE GENE POLYMORPHISM AND CORONARY ARTERY DISEASE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 13, no. 4, pp. 362–370, 2010, [Online]. Available: https://sid.ir/paper/75325/en

Related Journal Papers