مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

128
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

113
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

In-vitro Study of Hottentotta Schach Crude Venom Anticancer Effects on MCF-7 and Vero Cell Lines

Pages

  192-202

Abstract

 Scorpion venoms contain potentially useful pharmacological agents. Several studies demonstrate that the venoms of some scorpions induce apoptosis and inhibit the growth of cancer cells; therefore, they have been investigated for isolating anticancer components. In this study, antitumor effects of Hottentotta schach crude venom on MCF-7 (breast cancer cell line) as test group and Vero (African green monkey kidney normal cell line) as control group were analyzed. Cell toxicity was analyzed using MTT and neutral red (NR) uptake assays and apoptosis induction was analyzed using comet assay and caspase-3 activity. Oxidative stress following Hottentotta schach crude venom treatment was analyzed using nitrite oxide (NO) determination assay, reduced glutathione (GSH) and catalase enzyme activity assays. Results showed that crude venom (25-200 μ g/mL) induced apoptosis and inhibited the growth of MCF-7 and to a lesser extent in Vero cell lines. Nitrite oxide concentration increased while glutathione concentration and catalase enzyme activity were decreased in MCF-7 cells; however, results in Vero cells were reversed completely. It can be concluded that Hottentotta schach crude venom disturbs the oxidation and reduction potential in cancer cells and ultimately induce apoptosis. So this venom can be used as a good source for isolation and designing new anticancer drugs.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Dezianian, Saeed, ZARGAN, JAMIL, Goudarzi, Hamid Reza, Haji Noormohamadi, Ashkan, MOUSAVI, MOHSEN, Keshavarz Alikhani, Hani, & JOHARI, BEHROOZ. (2020). In-vitro Study of Hottentotta Schach Crude Venom Anticancer Effects on MCF-7 and Vero Cell Lines. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 19(1), 192-202. SID. https://sid.ir/paper/753385/en

    Vancouver: Copy

    Dezianian Saeed, ZARGAN JAMIL, Goudarzi Hamid Reza, Haji Noormohamadi Ashkan, MOUSAVI MOHSEN, Keshavarz Alikhani Hani, JOHARI BEHROOZ. In-vitro Study of Hottentotta Schach Crude Venom Anticancer Effects on MCF-7 and Vero Cell Lines. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2020;19(1):192-202. Available from: https://sid.ir/paper/753385/en

    IEEE: Copy

    Saeed Dezianian, JAMIL ZARGAN, Hamid Reza Goudarzi, Ashkan Haji Noormohamadi, MOHSEN MOUSAVI, Hani Keshavarz Alikhani, and BEHROOZ JOHARI, “In-vitro Study of Hottentotta Schach Crude Venom Anticancer Effects on MCF-7 and Vero Cell Lines,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 19, no. 1, pp. 192–202, 2020, [Online]. Available: https://sid.ir/paper/753385/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button