مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

193
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

108
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic)-induced metabolic disorders in rat

Pages

  1476-1482

Abstract

 Objective(s): Olanzapine, an atypical antipsychotic, causes weight gain and metabolic disorders in humans. Safranal, one of the active components of Crocus sativus (Saffron), has been shown to have anti-Obesity, lipid and blood pressure lowering and anti-diabetes effects. In this investigation, the effect of Safranal on metabolic disorders induced by Olanzapine was studied. Materials and Methods: Fourty-two female Wistar rats were divided into 7 groups of 6 animals. The two groups were selected as controls, which received Olanzapine and Safranal solvents, respectively. The third group treated by Olanzapine 5 mg/kg. Groups 4, 5 and 6 treated by Olanzapine 5 mg/kg plus Safranal (2. 5, 5 and 10 mg/kg) and the last group received Safranal 10 mg/kg. The injections were performed intraperitoneally for 14 days and on the 15th day the rats were killed and their serum were collected to measure metabolic factors including glucose, insulin, triglyceride, total cholesterol and HDL cholesterol. Leptin level in plasma was also measured. Mean systolic blood pressure was measured using tail cuff method at the end of study. The rats were weighed every other day and amount of food consumed was measured daily. Results: Olanzapine significantly elevated body weight, food intake, fasting blood glucose, TG, leptin, and mean systolic blood pressure (MSBP). It also significantly decreased HDL cholesterol blood level. Safranal significantly improved all these complications at three doses. Conclusion: Based on the results of this study, Safranal is thought to be used as an effective combination in controlling metabolic complications caused by Olanzapine.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Malekzadeh, Sara, HEIDARI, MAHMOOD REZA, RAZAVI, BIBI MARJAN, RAMESHRAD, MARYAM, & HOSSEINZADEH, HOSSEIN. (2019). Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic)-induced metabolic disorders in rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(12), 1476-1482. SID. https://sid.ir/paper/753703/en

    Vancouver: Copy

    Malekzadeh Sara, HEIDARI MAHMOOD REZA, RAZAVI BIBI MARJAN, RAMESHRAD MARYAM, HOSSEINZADEH HOSSEIN. Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic)-induced metabolic disorders in rat. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(12):1476-1482. Available from: https://sid.ir/paper/753703/en

    IEEE: Copy

    Sara Malekzadeh, MAHMOOD REZA HEIDARI, BIBI MARJAN RAZAVI, MARYAM RAMESHRAD, and HOSSEIN HOSSEINZADEH, “Effect of safranal, a constituent of saffron, on olanzapine (an atypical antipsychotic)-induced metabolic disorders in rat,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 12, pp. 1476–1482, 2019, [Online]. Available: https://sid.ir/paper/753703/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button