Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells

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FAGHIHLOO EBRAHIM; HAKEMI VALA MOJDEH; ESLAMI GITA; GOUDARZI HOSSEIN

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Journal Paper

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Journal: Archives of Clinical Infectious Diseases Year:2018 | Volume:13 | Issue:5 Page(s): 0-0

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Title

Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells

Author(s)

FAGHIHLOO EBRAHIM | HAKEMI VALA MOJDEH | ESLAMI GITA | GOUDARZI HOSSEIN | Issue Writer Certificate

Keywords

Cervical Cancer

HPV

Oxamflatin

E-cadherin

HeLa Cells

Abstract

Background: Cervical Cancer is currently among the most important causes of cancer-related deaths in women. The development of Cervical Cancer is associated with high-risk human papillomavirus (HPV) infections and a series of epigenetic changes in host cell genome, such as histone acetylation. Furthermore, decreased E-cadherin level has been shown to play a critical role in cancer cell invasion and metastasis. Oxamflatin has been reported to have anti-cancer efficacy. Objectives: We aimed to study the effect of this drugonCervical Cancer cell lines, HeLa Cells, by assessing E-cadherin level as a marker of cancer invasion susceptibility. Methods: HeLa Cells were treated with Oxamflatin, and total RNA was obtained. Then, quantitative real-time polymerase chain reaction (PCR) was performed to evaluate E-cadherin expression level in cells treated with Oxamflatin. Results: The findings of real-time PCR indicated that Oxamflatin increased E-cadherin level in a time-and concentration-dependent manner. The level of E-cadherin significantly increased at the concentrations of 4mM(for 24 hours after treatment) and 2 and 4mM (for 48 hours after treatment) in comparison with corresponding control HeLa Cells. Conclusions: The present study proposed that Oxamflatin may have anti-migratory and anti-invasive potential against Cervical Cancer cells, which should be further evaluated in future studies.

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APA: Copy

FAGHIHLOO, EBRAHIM, HAKEMI VALA, MOJDEH, ESLAMI, GITA, & GOUDARZI, HOSSEIN. (2018). Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 13(5), 0-0. SID. https://sid.ir/paper/753806/en

Vancouver: Copy

FAGHIHLOO EBRAHIM, HAKEMI VALA MOJDEH, ESLAMI GITA, GOUDARZI HOSSEIN. Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2018;13(5):0-0. Available from: https://sid.ir/paper/753806/en

IEEE: Copy

EBRAHIM FAGHIHLOO, MOJDEH HAKEMI VALA, GITA ESLAMI, and HOSSEIN GOUDARZI, “Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 13, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/753806/en

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