In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis

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Zadeh Mehrizi Tahereh; MOSAFFA NARIMAN; HAJI MOLLA HOSEINI MOSTAFA; SHAFIEE ARDESTANI MEHDI; KHAMESIPOUR ALI; EBRAHIMI SHAHMABADI HASAN; Pirali Hamedani Mostafa; Mardani Dashti Yasaman; RAMEZANI AMITIS

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Journal: Archives of Clinical Infectious Diseases Year:2018 | Volume:13 | Issue:5 Page(s): 0-0

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Title

In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis

Author(s)

Keywords

Histopathology

L.major

Nanochitosan

Nanodendrimer

Amphotericin B

Betulinic Acid

Abstract

Background: Nowadays, nanocarriers are used for leishmaniasis treatment due to development of drug resistance and several side effects with conventional therapeutics. Objectives: In this studyweaimed to evaluate in vivo effects of four synthesized nanodrugs including Amphotericin B-Nanochitosan (AK), Betulinic Acid-Nanochitosan (BK), Amphotericin B-dendrimer (AD), and Betulinic Acid-dendrimer (BD) in the treatment of Leishmania major infection (L. major) in mice model by using pathological analyses to choose the most effective nanodrug in leishmaniasis. Methods: The four nanodrugs efficacy in the improvement of L. major lesion in a mice model was evaluated by using pathological analyses including measurement of organs size and parasite number. Additionally, the nanodrugs toxicity was evaluated by measurement of various blood factors. Results: The histopathological results of the present study showed that BK, at the dose of 20 mg/kg, and AK, at the dose of 10 mg/kg, were more effective in decreasing the parasite number in the kidney, liver, and spleen. Moreover, BK20 mg/kg and AK10 mg/kg decreased the organs size significantly while AD50 mg/kg and BD40 mg/kg were less effective. However, none of the four nanodrugs had increased the blood factors and they were not toxic. Conclusions: Overall, the pathologic findings of various mice organs treated with different formulations showed that AK10 mg/kg and BK20 mg/kg were more effective in recovery of L. major’ s pathological effects in comparison to AD50 mg/kg and BD40 mg/kg. Therefore, it seems that AK and BK, in this mentioned dosage, could be considered as a proper candidate for treatment of leishmaniasis.

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APA: Copy

Zadeh Mehrizi, Tahereh, MOSAFFA, NARIMAN, HAJI MOLLA HOSEINI, MOSTAFA, SHAFIEE ARDESTANI, MEHDI, KHAMESIPOUR, ALI, EBRAHIMI SHAHMABADI, HASAN, Pirali Hamedani, Mostafa, Mardani Dashti, Yasaman, & RAMEZANI, AMITIS. (2018). In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 13(5), 0-0. SID. https://sid.ir/paper/753807/en

Vancouver: Copy

Zadeh Mehrizi Tahereh, MOSAFFA NARIMAN, HAJI MOLLA HOSEINI MOSTAFA, SHAFIEE ARDESTANI MEHDI, KHAMESIPOUR ALI, EBRAHIMI SHAHMABADI HASAN, Pirali Hamedani Mostafa, Mardani Dashti Yasaman, RAMEZANI AMITIS. In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis. ARCHIVES OF CLINICAL INFECTIOUS DISEASES[Internet]. 2018;13(5):0-0. Available from: https://sid.ir/paper/753807/en

IEEE: Copy

Tahereh Zadeh Mehrizi, NARIMAN MOSAFFA, MOSTAFA HAJI MOLLA HOSEINI, MEHDI SHAFIEE ARDESTANI, ALI KHAMESIPOUR, HASAN EBRAHIMI SHAHMABADI, Mostafa Pirali Hamedani, Yasaman Mardani Dashti, and AMITIS RAMEZANI, “In Vivo Therapeutic Effects of Four Synthesized Antileishmanial Nanodrugs in the Treatment of Leishmaniasis,” ARCHIVES OF CLINICAL INFECTIOUS DISEASES, vol. 13, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/753807/en

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