Celecoxib, Angiogenesis, and Wound Healing (Short Communication)

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Norooznezhad Amir Hossein; Norooznezhad Fatemeh; MOSTAFAIE ALI

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Journal: ImmunoRegulation Year:2020 | Volume:2 | Issue:2 Page(s): 121-124

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Information Journal Paper

Title

Celecoxib, Angiogenesis, and Wound Healing (Short Communication)

Author(s)

Norooznezhad Amir Hossein | Norooznezhad Fatemeh | MOSTAFAIE ALI | Issue Writer Certificate

Keywords

Celecoxib

Angiogenesis

Wound healing

Cyclooxygenase-2 (COX-2) inhibitor

Abstract

Background: Wounds and their healing process are among the most crucial medical issues, especially in the field of dermatology and surgery that imposes notable costs to the health care system. Materials and Methods: Wound healing requires specific fundamental steps, such as Angiogenesis and inflammation. Angiogenesis is controlled by different cytokines such as Hypoxia-Inducible Factor α (HIF-α ), Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), Platelet-Derived Growth Factor (PDGF), Tumor Necrosis Factor α (TNF-α ), and Matrix MetalloProteinases (MMPs). Results: Celecoxib, an inhibitor of Cyclooxygenase-2 (COX-2), is widely used in medicine and different fields. This medication can inhibit Angiogenesis via suppressing all mentioned cytokines. Thus, suppression of Angiogenesis by Celecoxib, especially in chronic wounds, may result in the poor or delayed healing. Conclusion: Authors suggest complementary clinical studies to evaluate the possible role of Celecoxib on the Wound healing focusing on Angiogenesis.

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APA: Copy

Norooznezhad, Amir Hossein, Norooznezhad, Fatemeh, & MOSTAFAIE, ALI. (2020). Celecoxib, Angiogenesis, and Wound Healing (Short Communication). IMMUNOREGULATION, 2(2), 121-124. SID. https://sid.ir/paper/754027/en

Vancouver: Copy

Norooznezhad Amir Hossein, Norooznezhad Fatemeh, MOSTAFAIE ALI. Celecoxib, Angiogenesis, and Wound Healing (Short Communication). IMMUNOREGULATION[Internet]. 2020;2(2):121-124. Available from: https://sid.ir/paper/754027/en

IEEE: Copy

Amir Hossein Norooznezhad, Fatemeh Norooznezhad, and ALI MOSTAFAIE, “Celecoxib, Angiogenesis, and Wound Healing (Short Communication),” IMMUNOREGULATION, vol. 2, no. 2, pp. 121–124, 2020, [Online]. Available: https://sid.ir/paper/754027/en

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