Hydroxychloroquine-induced Unusual Generalized Pustular Cutaneous Reaction As a New Clinical Entity: A Case Series

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BEHRANGI ELHAM; HALLAJI ZAHRA; GHIASI MARYAM; ABEDINI ROBABEH; GHANADAN ALIREZA; KHODASHENASE ZOHREH; GOODARZI AZADEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ImmunoRegulation Year:2020 | Volume:3 | Issue:1 Page(s): 67-72

Download Full-Text

View:

123

Download:

Cites:

Information Journal Paper

Title

Hydroxychloroquine-induced Unusual Generalized Pustular Cutaneous Reaction As a New Clinical Entity: A Case Series

Author(s)

Keywords

Hydroxychloroquine (HCQ)

Pustular eruption

Pustular Psoriasis (PP)

Acute Generalized Exanthematous Pustulosis (AGEP)

Abstract

Background: Pustular Psoriasis (PP) and Acute Generalized Exanthematous Pustulosis (AGEP) clinically resemble each other. There are many patients with generalized pustular presentations like hydroxychloroquine-induced pustular reaction who do not completely fall within PP or AGEP categories and needed to be more evaluated. So we examined a large series of these reactions to hydroxychloroquine (HCQ) and reviewed the literature in this regard. Materials and Methods: Records of 20 patients admitted to Razi Hospital, Tehran, Iran with acute onset of generalized Pustular eruption following hydroxychloroquine therapy were retrieved, and their demographic and clinical features were reviewed. In the meantime, all related articles in PubMed and Google scholar databases were studied as well. Results: All 20 patients were female with an Mean± SD age of 48. 35± 13. 76 years. The Mean± SD between the first dose and skin eruption was 3. 62± 1. 42 weeks. HCQ was prescribed for them, mainly for rheumatologic conditions and joint problems other than psoriasis. Treatment was planned according to the first clinical judgment, pathological findings, and clinical behavior of the disease. Eleven patients were treated as PP and 9 as AGEP. Conclusion: No evident history of psoriasis, drug-related eruption, as well as rapid and complete response to steroids in some patients, favor AGEP diagnosis. However, the long interval of symptoms appearance, prolonged disease course, relapses despite discontinuation of the responsible drug, and no appropriate response to the steroid, favor PP. So, it could be a new entity.

Cites

No record.

References

Cite

APA: Copy

BEHRANGI, ELHAM, HALLAJI, ZAHRA, GHIASI, MARYAM, ABEDINI, ROBABEH, GHANADAN, ALIREZA, KHODASHENASE, ZOHREH, & GOODARZI, AZADEH. (2020). Hydroxychloroquine-induced Unusual Generalized Pustular Cutaneous Reaction As a New Clinical Entity: A Case Series. IMMUNOREGULATION, 3(1), 67-72. SID. https://sid.ir/paper/754042/en

Vancouver: Copy

BEHRANGI ELHAM, HALLAJI ZAHRA, GHIASI MARYAM, ABEDINI ROBABEH, GHANADAN ALIREZA, KHODASHENASE ZOHREH, GOODARZI AZADEH. Hydroxychloroquine-induced Unusual Generalized Pustular Cutaneous Reaction As a New Clinical Entity: A Case Series. IMMUNOREGULATION[Internet]. 2020;3(1):67-72. Available from: https://sid.ir/paper/754042/en

IEEE: Copy

ELHAM BEHRANGI, ZAHRA HALLAJI, MARYAM GHIASI, ROBABEH ABEDINI, ALIREZA GHANADAN, ZOHREH KHODASHENASE, and AZADEH GOODARZI, “Hydroxychloroquine-induced Unusual Generalized Pustular Cutaneous Reaction As a New Clinical Entity: A Case Series,” IMMUNOREGULATION, vol. 3, no. 1, pp. 67–72, 2020, [Online]. Available: https://sid.ir/paper/754042/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops