Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis (CURRENT CONCEPTS REVIEW)

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Singh Vishavpreet; Oliashirazi Ali; Tan Timothy; Fayyad Azzam; Shahi Alisina

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Journal: Archives of Bone and Joint Surgery Year:2019 | Volume:7 | Issue:3 Page(s): 211-219

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Title

Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis (CURRENT CONCEPTS REVIEW)

Author(s)

Keywords

Bone marrow lesions (BML)

Knee osteoarthritis

Magnetic resonance imaging (MRI)

Abstract

Knee osteoarthritis (OA) affects the joint beyond just the articular cartilage. Specifically, magnetic resonance imagingidentified bone marrow lesions (BML) in the subchondral bone have both clinical and pathophysiological significance. Compared to joint space narrowing on traditional radiographs, the presence of BMLs has been better correlated with severity of clinical symptoms as well as clinical deterioration. Presence of a BML increases the likelihood for progression to a total knee arthroplasty by up to nine fold. Histochemical analysis of BMLs has shown increased levels of tumor necrosis factor-alpha, matrix metalloproteinases and substance P, thought to stimulate pain receptors in osteoarthritis.

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APA: Copy

Singh, Vishavpreet, Oliashirazi, Ali, Tan, Timothy, Fayyad, Azzam, & Shahi, Alisina. (2019). Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis (CURRENT CONCEPTS REVIEW). THE ARCHIVES OF BONE AND JOINT SURGERY, 7(3), 211-219. SID. https://sid.ir/paper/755048/en

Vancouver: Copy

Singh Vishavpreet, Oliashirazi Ali, Tan Timothy, Fayyad Azzam, Shahi Alisina. Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis (CURRENT CONCEPTS REVIEW). THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2019;7(3):211-219. Available from: https://sid.ir/paper/755048/en

IEEE: Copy

Vishavpreet Singh, Ali Oliashirazi, Timothy Tan, Azzam Fayyad, and Alisina Shahi, “Clinical and Pathophysiologic Significance of MRI Identified Bone Marrow Lesions Associated with Knee Osteoarthritis (CURRENT CONCEPTS REVIEW),” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 7, no. 3, pp. 211–219, 2019, [Online]. Available: https://sid.ir/paper/755048/en

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