Skin Mast Cell Promotion in Random Skin Flaps in Rats using Bone Marrow Mesenchymal Stem Cells and Amniotic Membrane

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CHEHELCHERAGHI FARZANEH; ABBASZADEH ABOLFAZL; Tavafi Magid

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Journal Paper

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Journal: Iranian Biomedical Journal Year:2018 | Volume:22 | Issue:5 Page(s): 322-330

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Title

Skin Mast Cell Promotion in Random Skin Flaps in Rats using Bone Marrow Mesenchymal Stem Cells and Amniotic Membrane

Author(s)

CHEHELCHERAGHI FARZANEH | ABBASZADEH ABOLFAZL | Tavafi Magid | Issue Writer Certificate

Keywords

Angiogenesis

Necrosis

Mast cells

Reconstructive surgical procedures

Surgical flaps

Abstract

Background: Skin flap procedures are employed in plastic surgery, but failure can lead to Necrosis of the flap. Studies have used bone marrow mesenchymal stem cells (BM-MSCs) to improve flap viability. BM-MSCs and acellular amniotic membrane (AAM) have been introduced as alternatives. The objective of this study was to evaluate the effect of BM-MSCs and AAM on Mast cells of random skin flaps (RSF) in rats. Methods: RSFs (80 × 30 mm) were created on 40 rats that were randomly assigned to one of four groups, including (I) AAM, (II) BM-MSCs, (III) BM-MSCs/AAM, and (IV) saline (control). Transplantation was carried out during the procedure (zero day). Flap Necrosis was observed on day 7, and skin samples were collected from the transition line of the flap to evaluate the total number and types of Mast cells. The development and the total number of Mast cells were related to the development of capillaries. Results: The results of one-way ANOVA indicated that there was no statistically significant difference between the mean numbers of mast cell types for different study groups. However, the difference between the total number of Mast cells in the study groups was statistically significant (p = 0. 001). Conclusion: The present study suggests that the use of AAM/BM-MSCs can improve the total number of Mast cells and accelerate the growth of capillaries at the transient site in RSFs in rats.

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APA: Copy

CHEHELCHERAGHI, FARZANEH, ABBASZADEH, ABOLFAZL, & Tavafi, Magid. (2018). Skin Mast Cell Promotion in Random Skin Flaps in Rats using Bone Marrow Mesenchymal Stem Cells and Amniotic Membrane. IRANIAN BIOMEDICAL JOURNAL, 22(5), 322-330. SID. https://sid.ir/paper/755237/en

Vancouver: Copy

CHEHELCHERAGHI FARZANEH, ABBASZADEH ABOLFAZL, Tavafi Magid. Skin Mast Cell Promotion in Random Skin Flaps in Rats using Bone Marrow Mesenchymal Stem Cells and Amniotic Membrane. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(5):322-330. Available from: https://sid.ir/paper/755237/en

IEEE: Copy

FARZANEH CHEHELCHERAGHI, ABOLFAZL ABBASZADEH, and Magid Tavafi, “Skin Mast Cell Promotion in Random Skin Flaps in Rats using Bone Marrow Mesenchymal Stem Cells and Amniotic Membrane,” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 5, pp. 322–330, 2018, [Online]. Available: https://sid.ir/paper/755237/en

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