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Information Journal Paper

Title

Curcumin Inhibited Endothelin-1 mRNA Expression Induced by TGF- in Bovine Aortic Endothelial Cell

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Abstract

 Objectives: Curcumin is a plant polyphenol compound used as a traditional supplement in many countries. The potential therapeutic or preventive effects of Curcumin may be related to its antioxidant and anti-inflammatory properties. The current in vitro study aimed to investigate the effect of Curcumin on the expression of Endothelin-1 (ET-1) stimulated by transforming growth factorbeta (TGF- ) in bovine aortic endothelial cells (BAECs). Methods: Bovine aortic endothelial cells derived from bovine aorta were maintained in low glucose DMEM (Dulbecco’ s modified Eagle’ s medium). The time-course and different concentrations of TGF- (2 ng/mL and 10 ng/mL) were used to evaluate ET-1 mRNA expression. Also, the BAECs were treated with 10 Mof SB431542 (chemical inhibitor of TGF- receptor) as positive control and different doses of Curcumin (5  M, 10  M, and 15  M). The expression of ET-1 mRNA was quantified by quantitative real-time polymerase chain reaction (qPCR). Statistical analysis was performed by one-way ANOVA with SPSS software. Results: ET-1 mRNA expression significantly increased in six hours in the TGF- -treated group (2. 79  0. 9). SB431542, as well as Curcumin 10  Mand 15  Msignificantly decreased the expression of ET-1mRNA by 2. 3 0. 15, 1. 5 0. 16, and 1. 02 0. 01, respectively. Conclusions: Curcumin downregulated ET-1 mRNA; this result suggested a possible underlying molecular mechanism mediated through ET-1 to exert its anti-inflammatory and antioxidant properties.

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    APA: Copy

    KESHAVARZ, ZAHRA, KHEIROLLAH, ALIREZA, GHAFFARI, MOHAMMAD ALI, & BABAAHMADI REZAEI, HOSSEIN. (2019). Curcumin Inhibited Endothelin-1 mRNA Expression Induced by TGF- in Bovine Aortic Endothelial Cell. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 14(1), 0-0. SID. https://sid.ir/paper/755354/en

    Vancouver: Copy

    KESHAVARZ ZAHRA, KHEIROLLAH ALIREZA, GHAFFARI MOHAMMAD ALI, BABAAHMADI REZAEI HOSSEIN. Curcumin Inhibited Endothelin-1 mRNA Expression Induced by TGF- in Bovine Aortic Endothelial Cell. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS[Internet]. 2019;14(1):0-0. Available from: https://sid.ir/paper/755354/en

    IEEE: Copy

    ZAHRA KESHAVARZ, ALIREZA KHEIROLLAH, MOHAMMAD ALI GHAFFARI, and HOSSEIN BABAAHMADI REZAEI, “Curcumin Inhibited Endothelin-1 mRNA Expression Induced by TGF- in Bovine Aortic Endothelial Cell,” JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 14, no. 1, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/755354/en

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