Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?

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PEZESHGI AIYOUB; Behmanesh Alireza; ESMAEILZADEH ABDOLREZA; Chiti Hossein; Kamali Kurosh; HEDAIATY MAHRANG

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Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2020 | Volume:9 | Issue:2 Page(s): 0-0

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Title

Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?

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Keywords

Coronary artery bypass graft

Acute kidney injury

Neutrophil gelatinase-associated lipocalin

Abstract

Introduction: The role of urinary Neutrophil gelatinase-associated lipocalin (NGAL) as a prognostic biomarker in Acute kidney injury (AKI) associated with coronary bypass graft has been suggested in some studies. However, the results have been inconclusive in different studies. Objectives: In the present research, we investigated the diagnostic and prognostic roles of NGAL in Iranian patients who developed AKI after coronary bypass surgery. Patients and Methods: This study was cross-sectional conducted on adult patients undergoing Coronary artery bypass graft (CABG) surgery. Postoperative AKI was defined based on the RIFLE (risk, injury, failure, loss and end-stage kidney disease) criteria. Patients were divided into AKI and non-AKI groups. The urinary NGAL and serum creatinine levels were measured at different times after surgery. Results: Out of 29 patients, men constituted 75. 9% of cases. Mean age of the patients was 61. 4± 7. 7 years old and the mean duration of surgery was 4. 9 ± 0. 6 hours. Based on serum creatinine, AKI was diagnosed in 37. 9%, 17. 25%, and 13. 8% of patients at first, second, and third day post-surgery, respectively. The urine NGAL increased by 48. 35% and 34. 5% at 2 and 6 hours after surgery, respectively. However, there was no significant association between the urinary NGAL level and the incidence of post-surgery AKI. Conclusion: This study showed that urinary NGAL was inapplicable to independently diagnose or predict the outcome of transient AKI associated with CABG.

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APA: Copy

PEZESHGI, AIYOUB, Behmanesh, Alireza, ESMAEILZADEH, ABDOLREZA, Chiti, Hossein, Kamali, Kurosh, & HEDAIATY, MAHRANG. (2020). Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?. JOURNAL OF RENAL INJURY PREVENTION, 9(2), 0-0. SID. https://sid.ir/paper/755545/en

Vancouver: Copy

PEZESHGI AIYOUB, Behmanesh Alireza, ESMAEILZADEH ABDOLREZA, Chiti Hossein, Kamali Kurosh, HEDAIATY MAHRANG. Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2020;9(2):0-0. Available from: https://sid.ir/paper/755545/en

IEEE: Copy

AIYOUB PEZESHGI, Alireza Behmanesh, ABDOLREZA ESMAEILZADEH, Hossein Chiti, Kurosh Kamali, and MAHRANG HEDAIATY, “Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?,” JOURNAL OF RENAL INJURY PREVENTION, vol. 9, no. 2, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/755545/en

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