Occurrence and Antibiogram of Extended-Spectrum Cephalosporin-and Cephamycin-Resistant Escherichia coli in Asymptomatic University Students

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Anyanwu Madubuike Umunna; Okpalanwa Chiamaka Felicitas; Ugwuanyi Raymond Nduka

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Journal: International Journal of Enteric Pathogens Year:2019 | Volume:7 | Issue:2 Page(s): 31-36

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Title

Occurrence and Antibiogram of Extended-Spectrum Cephalosporin-and Cephamycin-Resistant Escherichia coli in Asymptomatic University Students

Author(s)

Anyanwu Madubuike Umunna | Okpalanwa Chiamaka Felicitas | Ugwuanyi Raymond Nduka | Issue Writer Certificate

Keywords

Escherichia coli

Healthy university students

Cefoxitin resistance

Extended-spectrum β-lactam resistance

Extended-spectrum β-lactamase production

Abstract

Background: Apparently healthy individuals could serve as reservoirs and disseminators of extended-spectrum cephalosporin (ESC)-and cephamycin (cefoxitin, FOX)-resistant, and extended-spectrum β-lactamase-producing (ESBL-P) Escherichia coli which jeopardizes antibacterial therapy thereby posing a threat to the health of infected individuals/carriers. Objectives: This study aimed to screen healthy asymptomatic students in the University of Nigeria, Nsukka (UNN) as potential reservoirs of ESC-and FOX-resistant and ESBL-P E. coli and to determine the antibacterial resistance profile. Materials and Methods: Anal swabs were collected from 190 randomly selected healthy asymptomatic students of both genders in UNN between March and July 2018. ESC-resistant E. coli was isolated using MacConkey agar with 2 μ g/mL ceftazidime. ESBL production was assessed by combination disc method while cephamycin resistance was determined using cefoxitin disc screening. Phenotypic resistance of the isolates was determined using disc diffusion method. Results: Out of 190 samples, 20 (10. 2%) demonstrated growth. Of these, 6 (30%) were FOX resistant (putative AmpC-producers) but none produced ESBL. The resistance of the isolates was 100% to ampicillin (AMP), 95% to ceftazidime (CAZ), tetracycline (TET) and sulfamethoxazole-trimethoprim (SXT), 30% to FOX and chloramphenicol (CHL), 85% to ciprofloxacin (CIP), enrofloxacin (ENR) and streptomycin (STR), and 65% to kanamycin (KAN). All the isolates were susceptible to meropenem (MEM). Among the 20 isolates, 1 (5%) was resistant to 2 classes of antibacterial agents while 19 (95%), including all the FOX-resistant strains, were resistant to ≥ 3 classes of antibacterial agents. The isolates exhibited 11 multiple antibacterial resistance patterns with AMP, CAZ, FOX, TET, CIP, ENR, STR, KAN, SXT being predominant. Conclusion: Healthy asymptomatic students in UNN are potential reservoirs and disseminators of ESC-and cephamycin (FOX)-resistant E. coli.

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APA: Copy

Anyanwu, Madubuike Umunna, Okpalanwa, Chiamaka Felicitas, & Ugwuanyi, Raymond Nduka. (2019). Occurrence and Antibiogram of Extended-Spectrum Cephalosporin-and Cephamycin-Resistant Escherichia coli in Asymptomatic University Students. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, 7(2), 31-36. SID. https://sid.ir/paper/755710/en

Vancouver: Copy

Anyanwu Madubuike Umunna, Okpalanwa Chiamaka Felicitas, Ugwuanyi Raymond Nduka. Occurrence and Antibiogram of Extended-Spectrum Cephalosporin-and Cephamycin-Resistant Escherichia coli in Asymptomatic University Students. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN[Internet]. 2019;7(2):31-36. Available from: https://sid.ir/paper/755710/en

IEEE: Copy

Madubuike Umunna Anyanwu, Chiamaka Felicitas Okpalanwa, and Raymond Nduka Ugwuanyi, “Occurrence and Antibiogram of Extended-Spectrum Cephalosporin-and Cephamycin-Resistant Escherichia coli in Asymptomatic University Students,” INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, vol. 7, no. 2, pp. 31–36, 2019, [Online]. Available: https://sid.ir/paper/755710/en

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