Dispersive Solid Phase Extraction Using Magnetic Nanoparticles Performed in a Narrow-Bored Tube for Extraction of Atorvastatin, Losartan, and Valsartan in Plasma

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARAJZADEH MIR ALI; Yadeghari Adeleh; ABBASPOUR MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 138-146

Download Full-Text

View:

107

Download:

113

Cites:

Information Journal Paper

Title

Dispersive Solid Phase Extraction Using Magnetic Nanoparticles Performed in a Narrow-Bored Tube for Extraction of Atorvastatin, Losartan, and Valsartan in Plasma

Author(s)

FARAJZADEH MIR ALI | Yadeghari Adeleh | ABBASPOUR MARYAM | Issue Writer Certificate

Keywords

High-performance liquid chromatography

Magnetic solid phase extraction

Plasma

Atorvastatin

Losartan

Valsartan

Abstract

Purpose: In this investigation, a new version of Magnetic solid phase extraction (MSPE) performed in a narrow– bore tube has been proposed. In this study, hydrophobic octyl (C8) functionalized Fe3O4 magnetic nanoparticles (MNPs) stabilized by SiOH groups (Fe3O4@SiO2@C8) are used as magnetic nano– sorbents for the extraction of cardiovascular drugs from human Plasma prior to their determination by high performance liquid chromatography– photodiode array detection. Methods: After precipitation of the Plasma proteins, the supernatant is diluted with deionized water and filled into the narrow– bore tube. Then mg– level of the sorbent is added into the tube. The sorbent is dispersed and moved down through the solution instead of passing the solution from the cartridge. Using an external magnet, the collected nano– sorbents at the bottom of the tube are transferred on top of the solution and released to move down through the solution for three times to increase the extraction efficiency. Results: The linearity of the assay was ranging from 0. 4– 500 mg mL-1. The limits of detection and quantification of the method were obtained in the ranges of 0. 05– 0. 07 and 0. 16– 0. 24 mg L-1, respectively. The extraction recoveries were obtained in the range of 31– 49%. Intra– and inter– day precisions were calculated and obtained in the ranges of 5– 8 and 7%– 9% for 0. 5 mg L-1 of each analyte, and 5– 6 and 6%– 8% for 2 mg L-1 of each analyte, respectively. Conclusion: The proposed method was successfully used in determination of the studied drugs in patient’ s Plasmas.

Cites

No record.

References

No record.

Cite

APA: Copy

FARAJZADEH, MIR ALI, Yadeghari, Adeleh, & ABBASPOUR, MARYAM. (2019). Dispersive Solid Phase Extraction Using Magnetic Nanoparticles Performed in a Narrow-Bored Tube for Extraction of Atorvastatin, Losartan, and Valsartan in Plasma. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 138-146. SID. https://sid.ir/paper/755772/en

Vancouver: Copy

FARAJZADEH MIR ALI, Yadeghari Adeleh, ABBASPOUR MARYAM. Dispersive Solid Phase Extraction Using Magnetic Nanoparticles Performed in a Narrow-Bored Tube for Extraction of Atorvastatin, Losartan, and Valsartan in Plasma. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):138-146. Available from: https://sid.ir/paper/755772/en

IEEE: Copy

MIR ALI FARAJZADEH, Adeleh Yadeghari, and MARYAM ABBASPOUR, “Dispersive Solid Phase Extraction Using Magnetic Nanoparticles Performed in a Narrow-Bored Tube for Extraction of Atorvastatin, Losartan, and Valsartan in Plasma,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 138–146, 2019, [Online]. Available: https://sid.ir/paper/755772/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops