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Title

Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial

Pages

  123-130

Abstract

 Purpose: Adipose tissue is a highly active endocrine organ which plays a key role in energy homeostasis. The aim of this study was to determine the effects of dried Licorice extract along with a Calorie restricted diet on body composition, Insulin Resistance and Adipokines in overweight and obese subjects. Methods: Sixty-four overweight and obese volunteers (27 men, 37 women) were recruited into this double-blind, placebo-controlled, randomized, clinical trial. Participants were randomly allocated to the Licorice (n=32) or the placebo group (n=32), and each group received a low-calorie diet with either 1. 5 g/day of Licorice extract or placebo for 8 weeks. Biochemical parameters, anthropometric indices, body composition and dietary intake were measured at baseline and at the end of the study. Results: A total of 58 subjects completed the trial. No side effects were observed following Licorice supplementation. At the end of the study, waist circumference, fat mass, serum levels of vaspin, zinc-α 2 glycoprotein, insulin and HOMA-IR were significantly decreased in the intervention group, but only the reduction in serum vaspin levels in the Licorice group was significant when compared to the placebo group (p<0. 01). Conclusion: Supplementation with dried Licorice extract plus a low-calorie diet can increase vaspin levels in obese subjects. However, the anti-Obesity effects of the intervention were not stronger than a low-calorie diet alone in the management of Obesity.

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    APA: Copy

    ALIZADEH, MOHAMMAD, NAMAZI, NAZLI, MIRTAHERI, ELHAM, SARGHEINI, NAFISEH, & KHEIROURI, SORAYYA. (2018). Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial. ADVANCED PHARMACEUTICAL BULLETIN, 8(1), 123-130. SID. https://sid.ir/paper/756166/en

    Vancouver: Copy

    ALIZADEH MOHAMMAD, NAMAZI NAZLI, MIRTAHERI ELHAM, SARGHEINI NAFISEH, KHEIROURI SORAYYA. Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(1):123-130. Available from: https://sid.ir/paper/756166/en

    IEEE: Copy

    MOHAMMAD ALIZADEH, NAZLI NAMAZI, ELHAM MIRTAHERI, NAFISEH SARGHEINI, and SORAYYA KHEIROURI, “Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 1, pp. 123–130, 2018, [Online]. Available: https://sid.ir/paper/756166/en

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