Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive

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SOHRABI YOUSEF; Mohammadzadeh Aghdash Hossein; Baghbani Elham; DEHGHAN PARVIN; EZZATI NAZHAD DOLATABADI JAFAR

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2018 | Volume:8 | Issue:2 Page(s): 341-346

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Information Journal Paper

Title

Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive

Author(s)

Keywords

Ascorbyl palmitate (AP)

Apoptosis

Cytotoxicity

Genotoxicity

Flow cytometry Real-time PCR

Abstract

Purpose: Ascorbyl palmitate (AP) is a widely used food additive in food industry. In this study, AP was evaluated for potential cyto-Genotoxicity on Human Umbilical Vein Endothelial Cells (HUVECs). Methods: MTT assay and flow cytometry analysis was used for Cytotoxicity evaluation, while Genotoxicity was carried out using DAPI staining assays and real time PCR. Results: The growth of HUVECs was decreased upon treatment with AP in dose-and timedependent manner. Early/late Apoptosis percentage in HUVECs treated with this additive was detected using flow cytometry analysis. Also morphology of DAPI stained HUVECs clearly showed chromatin fragmentation. Furthermore, real time PCR results showed that AP induces Apoptosis by up-regulation of caspase-3, 9 and down-regulation of Bcl-2 ratio. Conclusion: The present results indicated that AP has capability to induce Apoptosis in HUVECs and its better to make a thorough analysis about its extensive application in food industry.

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APA: Copy

SOHRABI, YOUSEF, Mohammadzadeh Aghdash, Hossein, Baghbani, Elham, DEHGHAN, PARVIN, & EZZATI NAZHAD DOLATABADI, JAFAR. (2018). Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive. ADVANCED PHARMACEUTICAL BULLETIN, 8(2), 341-346. SID. https://sid.ir/paper/756189/en

Vancouver: Copy

SOHRABI YOUSEF, Mohammadzadeh Aghdash Hossein, Baghbani Elham, DEHGHAN PARVIN, EZZATI NAZHAD DOLATABADI JAFAR. Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2018;8(2):341-346. Available from: https://sid.ir/paper/756189/en

IEEE: Copy

YOUSEF SOHRABI, Hossein Mohammadzadeh Aghdash, Elham Baghbani, PARVIN DEHGHAN, and JAFAR EZZATI NAZHAD DOLATABADI, “Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 8, no. 2, pp. 341–346, 2018, [Online]. Available: https://sid.ir/paper/756189/en

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