The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells

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MORAVEJ ALI; KOUHPAYEH AMIN; GERAMIZADEH BITA; AZARPIRA NEGAR; YAGHOBI RAMIN; Mansoori Yaser; KARIMI MOHAMMAD HOSSEIN

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Journal: Advanced Pharmaceutical Bulletin Year:2019 | Volume:9 | Issue:1 Page(s): 56-63

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Title

The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells

Author(s)

Keywords

MSCs

DCs

IDO

Qa2

Immunomodulation

Abstract

Purpose: Mesenchymal stem cells (MSCs) have been shown to reduce the activity of immune cells, including dendritic cells (DCs). But the exact mechanism of mesenchymal inhibition of DCs is still unknown. In this study, the effect of mesenchymal cells on the expression of indoleamine dioxygenase (IDO) and Qa2 molecules in DCs was evaluated. Methods: MSCs and DCs were respectively isolated from the bone marrow and spleen of BALB/c mice. Then DCs were co-cultured with MSCs in the present and absence of lipopolysaccharides (LPS). Then the expression of mRNA and protein of IDO and Qa2 molecules were investigated in DCs that were treated with MSCs. Results: The expression of IDO and Qa2 mRNA in DCs that were treated with MSCs did not significantly differ from the control group. The expression of IDO protein in DCs that were cocultured with MSCs (in 1: 10 and 1: 50 ratios) in absence of LPS was increased, although they were not statistically significant (P values: 0. 24 and 0. 18, respectively). The expression of Qa2 protein in DCs that were co-cultured with MSCs (in 1: 10 and 1: 50 ratios) in presence of LPS was increased, although they were not statistically significant (P-values: 0. 09 and 0. 33, respectively). Conclusion: Our results denied the possibility that MSCs led to the induction of tolerogenic DCs by increasing the expression of the IDO and Qa2 immunomodulatory molecules.

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APA: Copy

MORAVEJ, ALI, KOUHPAYEH, AMIN, GERAMIZADEH, BITA, AZARPIRA, NEGAR, YAGHOBI, RAMIN, Mansoori, Yaser, & KARIMI, MOHAMMAD HOSSEIN. (2019). The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells. ADVANCED PHARMACEUTICAL BULLETIN, 9(1), 56-63. SID. https://sid.ir/paper/756649/en

Vancouver: Copy

MORAVEJ ALI, KOUHPAYEH AMIN, GERAMIZADEH BITA, AZARPIRA NEGAR, YAGHOBI RAMIN, Mansoori Yaser, KARIMI MOHAMMAD HOSSEIN. The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2019;9(1):56-63. Available from: https://sid.ir/paper/756649/en

IEEE: Copy

ALI MORAVEJ, AMIN KOUHPAYEH, BITA GERAMIZADEH, NEGAR AZARPIRA, RAMIN YAGHOBI, Yaser Mansoori, and MOHAMMAD HOSSEIN KARIMI, “The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 9, no. 1, pp. 56–63, 2019, [Online]. Available: https://sid.ir/paper/756649/en

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