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Information Journal Paper

Title

Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells

Pages

  452-457

Abstract

 Purpose: Memantine is an approved drug for the treatment of Alzheimer’ s disease (AD). Autophagy, lysosome dysfunction, and Sigma receptors have possible roles in the pathophysiology of AD. Therefore, we aimed to investigate the contribution of Sigma receptors and lysosome inhibition to the neuroprotective effects of Memantine against amyloid-beta (Aβ )-induced neurotoxicity in SH-SY5Y cells. Methods: We determined the neuroprotective effects of Memantine (2. 5 μ M), dizocilpine (MK801, as a selective N-methyl-D-aspartate (NMDA) receptor antagonist) (5 μ M) against Aβ 25– 35 (2 μ g/μ L)-induced neurotoxicity. We used chloroquine (10, 20, and 40 μ M) as a lysosome inhibitor and BD-1063 (1, 10, and 30 μ M) as a selective sigma receptor antagonist. The MTT assay was used to measure the neurotoxicity in the SH-SY5Y cells. Data were analyzed using the one-way ANOVA. Results: Memantine (2. 5 μ M), dizocilpine (5 μ M), chloroquine (10 and 20 μ M) and BD-1063 (1, 10 and 30 μ M) decreased the neurotoxic effects of Aβ on the SH-SY5Y cells. However, chloroquine (40 μ M) increased the neurotoxic effects of Aβ . Cell viability in the cells treated with Memantine + Aβ + chloroquine (10, 20, and 40 μ M) was significantly lower than the Memantine + Aβ-treated group. Moreover, cell viability in the Memantine + Aβ group was higher than the Memantine + Aβ + BD-1063 (10 and 30 μ M) groups. Conclusion: The lysosomal and Sigma receptors may contribute to the neuroprotective mechanism of Memantine and other NMDA receptor antagonists. Moreover, the restoration of Lysosomes function and the modulation of Sigma receptors are potential targets in the treatment of AD.

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    APA: Copy

    KESHAVARZ, MOJTABA, Farrokhi, Majid Reza, Amirinezhad Fard, Elahe, & MEHDIPOUR, MOHAMMAD. (2020). Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells. ADVANCED PHARMACEUTICAL BULLETIN, 10(3), 452-457. SID. https://sid.ir/paper/756761/en

    Vancouver: Copy

    KESHAVARZ MOJTABA, Farrokhi Majid Reza, Amirinezhad Fard Elahe, MEHDIPOUR MOHAMMAD. Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2020;10(3):452-457. Available from: https://sid.ir/paper/756761/en

    IEEE: Copy

    MOJTABA KESHAVARZ, Majid Reza Farrokhi, Elahe Amirinezhad Fard, and MOHAMMAD MEHDIPOUR, “Contribution of Lysosome and Sigma Receptors to Neuroprotective Effects of Memantine Against Beta-Amyloid in the SH-SY5Y Cells,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 10, no. 3, pp. 452–457, 2020, [Online]. Available: https://sid.ir/paper/756761/en

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