The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

OVEISGHARAN SHAHRAM; KARIMI ZAHRA; ABDI SIAMAK; SIKAROODI HAJIR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Current Journal of Neurology Year:2019 | Volume:18 | Issue:2 Page(s): 57-63

Download Full-Text

View:

140

Download:

109

Cites:

Information Journal Paper

Title

The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study

Author(s)

OVEISGHARAN SHAHRAM | KARIMI ZAHRA | ABDI SIAMAK | SIKAROODI HAJIR | Issue Writer Certificate

Keywords

Multiple Sclerosis

Transcranial Direct Current Stimulation

Mobility Limitation

Abstract

Background: Transcranial Direct Current Stimulation (tDCS) of the primary motor cortex of the lower limb has been exploited in the treatment of patients with stroke and spastic lower limb paresis. We examined this stimulation efficacy in the treatment of Multiple Sclerosis (MS)-related walking disability. Methods: In a single-center randomized doubleblind clinical trial study, 13 patients with MS and walking disability and Expanded Disability Status Scale (EDSS) score of 3 to 6 were randomized to the real and sham stimulation groups. In the real tDCS stimulation, 7 patients received anodal 2. 5 mA stimulation at 1 cm anterior to the Cz point for 30-minute daily sessions in 7 consecutive days. The other group received sham stimulation with the same protocol. The primary outcome of the trial was change in the Timed 25-Foot Walk (T25-FW) from before to after the stimulation. We also assessed the Multiple Sclerosis Walking Scale-12 (MSWS-12). We employed linear mixed effects model to examine the efficacy of tDCS stimulation on changing the outcomes. Results: On average, patients who received real tDCS stimulation walked faster after 7 sessions of stimulation [Estimate =-2. 7, standard error (SE) = 1. 3, P = 0. 049], while walking speed of sham stimulation recipients did not change. For every session of stimulation, recipients of real tDCS stimulation spent 2. 7 seconds less for walking the 25 feet. Real tDCS stimulation was not effective in improving MSWS-12 scores. Conclusion: tDCS stimulation of the lower limb motor cortex speeded up patients with MS in walking, but without improvement in patients’ mobility in daily activities.

Cites

No record.

References

Cite

APA: Copy

OVEISGHARAN, SHAHRAM, KARIMI, ZAHRA, ABDI, SIAMAK, & SIKAROODI, HAJIR. (2019). The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 18(2), 57-63. SID. https://sid.ir/paper/756962/en

Vancouver: Copy

OVEISGHARAN SHAHRAM, KARIMI ZAHRA, ABDI SIAMAK, SIKAROODI HAJIR. The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2019;18(2):57-63. Available from: https://sid.ir/paper/756962/en

IEEE: Copy

SHAHRAM OVEISGHARAN, ZAHRA KARIMI, SIAMAK ABDI, and HAJIR SIKAROODI, “The use of brain stimulation in the rehabilitation of walking disability in patients with multiple sclerosis: A randomized double-blind clinical trial study,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 18, no. 2, pp. 57–63, 2019, [Online]. Available: https://sid.ir/paper/756962/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops