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Information Journal Paper

Title

A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

Pages

  1855-1860

Abstract

 Background: The Tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A Polymorphism and the risk of Breast cancer in a northeastern Iranian population. Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with Breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A Polymorphism and the risk of Breast cancer. Results: There was no significant association between the AA genotype of the p73 G4A Polymorphism and Breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of Breast cancer in this study group. Conclusion: There was no association between G4A p73 Polymorphism and the risk of Breast cancer in a northeastern Iranian population.

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    APA: Copy

    Tavakkol Afshari, Zeinab, Gholizadeh, Zahra, NIKPOOR, AMIN REZA, TAVAKKOL AFSHARI, JALIL, Ganjali, Rashin, HOMAEI SHANDIZ, FATEMEH, & Jamialahmadi, Khadijeh. (2019). A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population. IRANIAN JOURNAL OF PUBLIC HEALTH, 48(10), 1855-1860. SID. https://sid.ir/paper/757230/en

    Vancouver: Copy

    Tavakkol Afshari Zeinab, Gholizadeh Zahra, NIKPOOR AMIN REZA, TAVAKKOL AFSHARI JALIL, Ganjali Rashin, HOMAEI SHANDIZ FATEMEH, Jamialahmadi Khadijeh. A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2019;48(10):1855-1860. Available from: https://sid.ir/paper/757230/en

    IEEE: Copy

    Zeinab Tavakkol Afshari, Zahra Gholizadeh, AMIN REZA NIKPOOR, JALIL TAVAKKOL AFSHARI, Rashin Ganjali, FATEMEH HOMAEI SHANDIZ, and Khadijeh Jamialahmadi, “A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 48, no. 10, pp. 1855–1860, 2019, [Online]. Available: https://sid.ir/paper/757230/en

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