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Information Journal Paper

Title

Histomorphometric Analysis of Newly-formed Bone Using Octacalcium Phosphate and Bone Matrix Gelatin in Rat Tibial Defects

Pages

  182-190

Abstract

 Background: Repair of bone defects is challenging for reconstructive and orthopedic surgeons. In this study, we aimed to histomorphometrically assess new Bone formation in Tibial bone defects filled with Octacalcium phosphate (OCP), Bone matrix gelatin (BMG), and a combination of both. Methods: A total of 96 male Sprague Dawley Rats aged 6-8 weeks weighing 120-150 g were randomly allocated into three experimental (OCP, BMG, and OCP/BMG) and one control group (n=24 in each group). The defects in experimental groups were filled with OCP (6 mg), BMG (6 mg), or a combination of OCP and BMG (6 mg, 2: 1 Ratio). No material was used to fill the defects in the control group and the defect was only covered with Surgicel. Samples were taken on days 7, 14, 21, and 56 after the surgery. The sections were stained with hematoxylin-eosin (H&E) and assessed using light microscopy. Results: In our experimental groups, Bone formation was started from the margins of the defect towards the center with an increasing Rate during the study period. Moreover, the formed bone was more mature. Bone formation in our control group was only limited to the margins of the defect. The newly formed bone mass was significantly higher in the experimental groups (P=0. 001). Conclusion: OCP, BMG, and OCP/BMG compound enhanced osteoinduction in long bones.

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    APA: Copy

    SARGOLZAEI AVAL, FEREYDOON, Arab, Mohammad R., SARGOLZAEI, NARJES, Barfrushan, Sanam, MIR, MOHSEN, Sargazi, Gholam H., Sargolzaei Aval, Forough, & ARAB, MARYAM. (2019). Histomorphometric Analysis of Newly-formed Bone Using Octacalcium Phosphate and Bone Matrix Gelatin in Rat Tibial Defects. THE ARCHIVES OF BONE AND JOINT SURGERY, 7(2), 182-190. SID. https://sid.ir/paper/757311/en

    Vancouver: Copy

    SARGOLZAEI AVAL FEREYDOON, Arab Mohammad R., SARGOLZAEI NARJES, Barfrushan Sanam, MIR MOHSEN, Sargazi Gholam H., Sargolzaei Aval Forough, ARAB MARYAM. Histomorphometric Analysis of Newly-formed Bone Using Octacalcium Phosphate and Bone Matrix Gelatin in Rat Tibial Defects. THE ARCHIVES OF BONE AND JOINT SURGERY[Internet]. 2019;7(2):182-190. Available from: https://sid.ir/paper/757311/en

    IEEE: Copy

    FEREYDOON SARGOLZAEI AVAL, Mohammad R. Arab, NARJES SARGOLZAEI, Sanam Barfrushan, MOHSEN MIR, Gholam H. Sargazi, Forough Sargolzaei Aval, and MARYAM ARAB, “Histomorphometric Analysis of Newly-formed Bone Using Octacalcium Phosphate and Bone Matrix Gelatin in Rat Tibial Defects,” THE ARCHIVES OF BONE AND JOINT SURGERY, vol. 7, no. 2, pp. 182–190, 2019, [Online]. Available: https://sid.ir/paper/757311/en

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