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Information Journal Paper

Title

Coating Iron Oxide Nanoparticles with Chitosan for Targeted Delivery of Nanocurcumin

Pages

  0-0

Abstract

 Background: Curcumin is an active non-toxic component of turmeric and is a substance with strong anti-inflammatory and antioxidant properties. Iron, as a micronutrient, plays an important role in physiological processes. Chitosan is a natural polymer derived from chitin and is known as a biocompatible product due to its high biocompatibility, non-toxicity, and biodegradation to harmless products. Objectives: This study aimed to design and synthesize a modified magnetic nanoparticle to be used as a targeted drug delivery system. Methods: NanoCurcumin loading was performed on the surface of Chitosan-modified Iron magnetic Nanoparticles in two stages. In the first stage, Chitosan was loaded on the surface of Iron magnetic Nanoparticles as a coating polymer. In the next step, the final reaction took place by the loading of nanoCurcumin on the surface of magnetic Iron Nanoparticles modified by Chitosan. Results: The results of transmission electron microscopy and scanning electron microscopy demonstrated the structure, morphology, physicochemical properties, and presence of nanoCurcumin layers on Chitosan in Nanoparticles with a diameter of 20 nm. In the Fourier transform infrared spectroscopy, the Iron-oxygen peak indicated the magnetic Nanoparticles of Iron, and the oxygenhydrogen peak showed nanoCurcumin layers on Chitosan. Moreover, X-ray spectroscopy confirmed the presence of these elements in the final composition by showing Iron, carbon, oxygen, and nitrogen peaks. Conclusions: The results of this study showed that nanoCurcumin was successfully loadedon the surface of magnetic Iron Nanoparticles modified by Chitosan.

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    Cite

    APA: Copy

    HAMI, ZAHRA. (2020). Coating Iron Oxide Nanoparticles with Chitosan for Targeted Delivery of Nanocurcumin. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 18(1), 0-0. SID. https://sid.ir/paper/757853/en

    Vancouver: Copy

    HAMI ZAHRA. Coating Iron Oxide Nanoparticles with Chitosan for Targeted Delivery of Nanocurcumin. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2020;18(1):0-0. Available from: https://sid.ir/paper/757853/en

    IEEE: Copy

    ZAHRA HAMI, “Coating Iron Oxide Nanoparticles with Chitosan for Targeted Delivery of Nanocurcumin,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 18, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/757853/en

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