Validation of Billewicz Scoring System for Detection of Overt Hypothyroidism During Pregnancy

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NAZARPOUR SIMA; RAMEZANI TEHRANI FAHIMEH; RAHMATI MARYAM; MINOOEE SONIA; SIMBAR MASOUMEH; NOROOZZADEH MAHSA; AZIZI FEREIDOUN

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Journal Paper

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Journal: International Journal of Endocrinology and Metabolism Year:2018 | Volume:16 | Issue:3 Page(s): 0-0

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Title

Validation of Billewicz Scoring System for Detection of Overt Hypothyroidism During Pregnancy

Author(s)

Keywords

Hypothyroidism

Signs and Symptoms

Pregnancy

Abstract

Background: Currently, various clinical and laboratory diagnostic methods are used to detect overt Hypothyroidism during Pregnancy. The Billewicz scoring index, as a clinical scale for detection of Hypothyroidism, has been applied in general populations; however, its application during Pregnancy remains a controversial subject of ongoing research. Objectives: The purpose of this study was to evaluate the diagnostic value of Billewicz scoring index for overt Hypothyroidism in a general population of Iranian pregnant women. Methods: This study was conducted on 1843 pregnant women. A comprehensive questionnaire, including Billewicz scoring items, was completed, and relevant clinical examinations were performed. The participants underwent serum measurements of thyroxine (T4), thyroid hormone uptake, thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb). Using the receiver operating characteristic (ROC) curve analysis, the optimal sensitivity and specificity were determined as values with maximum yields on the Youden and Rsquo’ s Index (sensitivity + specificity-1). Results: The prevalence of overt Hypothyroidism and subclinical Hypothyroidism was 3. 3% and 28. 6%, respectively. Overall, 3. 6%, 18. 9%, and 50% of euthyroid, subclinical hypothyroid, and overt hypothyroid women were TPOAb-positive, respectively. The mean Billewicz scores of euthyroid, overt hypothyroid, and subclinical hypothyroid women were-41. 16 (11. 16),-17. 11 (13. 63), and-40. 1 (11. 2), respectively. Based on the Billewicz scale, at least one sign of Hypothyroidism was reported in 38. 84% (n, 491) of euthyroid women. Scores -26. 5 (sensitivity, 100%; specificity, 90. 82%) were considered as the optimal scores for predicting overt Hypothyroidism (Ldquo, Norisk, and Rsquo). Conclusions: The Billewicz clinical scoring system, as a reliable and inexpensive clinical tool, used along with laboratory measurements, can help screen overt Hypothyroidism during Pregnancy, primarily in low-resource settings.

Cites

Prevalence of Hypothyroidism and Pregnancy Outcomes in Women Referred to Ayatollah Mousavi Hospital in Zanjan in 2018-2019

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APA: Copy

NAZARPOUR, SIMA, RAMEZANI TEHRANI, FAHIMEH, MINOOEE, SONIA, SIMBAR, MASOUMEH, NOROOZZADEH, MAHSA, & AZIZI, FEREIDOUN. (2018). Validation of Billewicz Scoring System for Detection of Overt Hypothyroidism During Pregnancy. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(3), 0-0. SID. https://sid.ir/paper/758113/en

Vancouver: Copy

NAZARPOUR SIMA, RAMEZANI TEHRANI FAHIMEH, MINOOEE SONIA, SIMBAR MASOUMEH, NOROOZZADEH MAHSA, AZIZI FEREIDOUN. Validation of Billewicz Scoring System for Detection of Overt Hypothyroidism During Pregnancy. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;16(3):0-0. Available from: https://sid.ir/paper/758113/en

IEEE: Copy

SIMA NAZARPOUR, FAHIMEH RAMEZANI TEHRANI, SONIA MINOOEE, MASOUMEH SIMBAR, MAHSA NOROOZZADEH, and FEREIDOUN AZIZI, “Validation of Billewicz Scoring System for Detection of Overt Hypothyroidism During Pregnancy,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 16, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/758113/en

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