Outcomes of a Longitudinal Population-based Cohort Study and Pragmatic Community Trial: Findings from 20 Years of the Tehran Lipid and Glucose Study

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KHALILI DAVOOD; AZIZI FEREIDOUN; ASGARI SAMANEH; ZADEH VAKILI AZITA; MOMENAN AMIR ABBAS; GHANBARIAN ARASH; ESKANDARI FATEMEH; HAJSHEIKHOLESLAMI FARHAD; HADAEGH FARZAD

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Journal: International Journal of Endocrinology and Metabolism Year:2018 | Volume:16 | Issue:suppl 4 Page(s): 0-0

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Title

Outcomes of a Longitudinal Population-based Cohort Study and Pragmatic Community Trial: Findings from 20 Years of the Tehran Lipid and Glucose Study

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Keywords

TLGS

Non-Communicable Disease

Risk Factors

Abstract

Context: The Tehran lipid and glucose study (TLGS) is one of the oldest population-based longitudinal cohort studies, providing knowledge about the incidence and Risk Factors of some Non-Communicable Diseases (NCDs) inWest Asia which hitherto was relatively scarce. We reviewed the methods and results related to the outcome measurements of this study. Evidence Acquisition: We reviewed all the TLGS papers which reported the incidence of NCDs. Results: The TLGS was initiated in 1999-2001 on a population in district no. 13 of Tehran with the same age distribution of the overall Tehran population and with a middle socioeconomic status. Totally, 15005 individuals, aged 3 years, participated in the first examination; reexaminations were conducted in a triennial manner and 3550 individuals were added in the second examination. All participants were also followed up annually and asked about any medical event leading to hospitalization or death. A part of participants was assigned to an educational program for lifestyle modification. High incidence of cardiovascular disease (CVD), premature CVD, diabetes and hypertension (around 19, 6, 10 and 31 in men and 11, 5, 11 and 29 in women per 1000 person-year, respectively) besides the high incidence of pre-diabetes and pre-hypertension (around 46 and 76 in men and 37 and 49 in women per 1000 person-year, respectively) showed a worrying situation. Fortunately, the results of the community interventions were promising with around 20% reduction in the risk of metabolic syndrome up to six years. Conclusions: These precise detections of different outcomes in the TLGS provided valuable evidences for prediction and prevention of NCDs in Iran with some novelties in the middle-income countries in the world. The Tehran thyroid study (TTS) and the Tehran cardiometabolic genetic study (TCGS), conducted in the framework of the TLGS, areamongfew studies aiming to determine the natural course of thyroid function and to identify patterns of genetic polymorphisms related to cardiometabolic outcomes, respectively.

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APA: Copy

KHALILI, DAVOOD, AZIZI, FEREIDOUN, ASGARI, SAMANEH, ZADEH VAKILI, AZITA, MOMENAN, AMIR ABBAS, GHANBARIAN, ARASH, ESKANDARI, FATEMEH, HAJSHEIKHOLESLAMI, FARHAD, & HADAEGH, FARZAD. (2018). Outcomes of a Longitudinal Population-based Cohort Study and Pragmatic Community Trial: Findings from 20 Years of the Tehran Lipid and Glucose Study. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(4 (Suppl.)), 0-0. SID. https://sid.ir/paper/758116/en

Vancouver: Copy

KHALILI DAVOOD, AZIZI FEREIDOUN, ASGARI SAMANEH, ZADEH VAKILI AZITA, MOMENAN AMIR ABBAS, GHANBARIAN ARASH, ESKANDARI FATEMEH, HAJSHEIKHOLESLAMI FARHAD, HADAEGH FARZAD. Outcomes of a Longitudinal Population-based Cohort Study and Pragmatic Community Trial: Findings from 20 Years of the Tehran Lipid and Glucose Study. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;16(4 (Suppl.)):0-0. Available from: https://sid.ir/paper/758116/en

IEEE: Copy

DAVOOD KHALILI, FEREIDOUN AZIZI, SAMANEH ASGARI, AZITA ZADEH VAKILI, AMIR ABBAS MOMENAN, ARASH GHANBARIAN, FATEMEH ESKANDARI, FARHAD HAJSHEIKHOLESLAMI, and FARZAD HADAEGH, “Outcomes of a Longitudinal Population-based Cohort Study and Pragmatic Community Trial: Findings from 20 Years of the Tehran Lipid and Glucose Study,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 16, no. 4 (Suppl.), pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/758116/en

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