مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma

Pages

  160-170

Abstract

 Background: This study aimed to evaluate the diagnostic value of outer dense fiber 4 (ODF4), melanomaassociated antigen A3 (MAGEA3), and MAGEAB4 mRNAs in Transitional cell carcinoma (TCC), using a small amount of cell reverse transcriptase-polymerase chain reaction (RT-PCR) on urinary exfoliated cells. Methods: We recruited a total of 105 suspected TCC patients and 54 sex-and age-matched non-TCC controls. The candidates’ genetic expression patterns were investigated with RT-PCR, while reverse transcription quantitative PCR was applied to quantify and compare each mRNA level between cases and control groups. Results: The sensitivity of ODF4, MAGEA3, and MAGEAB4 RT-PCR was 54. 8%, 63%, and 53. 4%, whereas the specificity was 73. 7%, 86%, and 94. 7%, respectively. Combining ODF4, MAGEA3, and MAGEAB4 RT-PCR offered a relatively higher sensitivity (83. 6%). Conclusion: RT-PCR with ODF4, MAGEA3, and MAGEAB4 on urinary exfoliated cells could provide clinicians with a promising method to improve TCC diagnosis, especially in the case of gross hematuria and catheterization. The method used here is non-invasive, simple and convenient, and unlike cytology, it does not rely directly on expert professional opinions. These features can be of particular importance to the management of TCC patients in whom regular and lifelong surveillance is required.

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    APA: Copy

    Afsharpad, Mandana, NOWROOZI, MOHAMMAD REZA, AAYATI, MOHSEN, SAFFARI, MOJTABA, NEMATI, SAEED, MOHEBBI, ELHAM, Nekoohesh, Leila, ZENDEHDEL, KAZEM, & MODARRESSI, MOHAMMAD HOSSEIN. (2018). ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma. IRANIAN BIOMEDICAL JOURNAL, 22(3), 160-170. SID. https://sid.ir/paper/758222/en

    Vancouver: Copy

    Afsharpad Mandana, NOWROOZI MOHAMMAD REZA, AAYATI MOHSEN, SAFFARI MOJTABA, NEMATI SAEED, MOHEBBI ELHAM, Nekoohesh Leila, ZENDEHDEL KAZEM, MODARRESSI MOHAMMAD HOSSEIN. ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma. IRANIAN BIOMEDICAL JOURNAL[Internet]. 2018;22(3):160-170. Available from: https://sid.ir/paper/758222/en

    IEEE: Copy

    Mandana Afsharpad, MOHAMMAD REZA NOWROOZI, MOHSEN AAYATI, MOJTABA SAFFARI, SAEED NEMATI, ELHAM MOHEBBI, Leila Nekoohesh, KAZEM ZENDEHDEL, and MOHAMMAD HOSSEIN MODARRESSI, “ODF4, MAGEA3, and MAGEB4: Potential Biomarkers in Patients with Transitional Cell Carcinoma,” IRANIAN BIOMEDICAL JOURNAL, vol. 22, no. 3, pp. 160–170, 2018, [Online]. Available: https://sid.ir/paper/758222/en

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