Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NADI S.; BANAEI A.; MOZDARANI H.; SHABESTANI MONFARED A.; ATAEI G.R.; Abedi Firouzjah r.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2020 | Volume:18 | Issue:2 Page(s): 275-282

Download Full-Text

View:

161

Download:

116

Cites:

Information Journal Paper

Title

Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay

Author(s)

Keywords

Radiation

arbutin

hematopoietic

radioprotector

micronucleus assay

Abstract

Background: X-irRadiations induce damages to the hematopoietic system by reducing the production of blood cells in bone marrow. In this study, the radioprotective effect of arbutin was investigated in megavoltage x-irradiated mice by measuring changes in hematological parameters and lymphocyte cells with micronucleus assay. Material and Methods: Sixty NMRI mice were irradiated with 6 MV photon beam (2 and 4 Gy in one fraction). Various concentrations of arbutin (50, 100, and 200 mg/kg) were injected intraperitoneal, 2 hours before whole body X-irRadiation. Samples of peripheral blood cells were collected from the left ventricle. The frequency of micronuclei in 1000 cells were measured for each sample and level of peripheral blood cells were analyzed. The data were statistically evaluated using one-way ANOVA, and Tukey HSD test. Results: X-Radiations significantly decreased the hematological parameters such as white blood cells (WBC), lymphocyte (LYM), red blood cells (RBC) counts, and hemoglobin (HGB) levels compared to the control group (P < 0. 001). The frequency of micronuclei in “ 2 and 4 Gy X-irRadiation + distilled water” groups was significantly higher than “ 2 and 4 Gy irRadiation + 50 mg/kg arbutin” , “ 2 and 4 Gy irRadiation + 100 mg/ kg arbutin” , and “ 2 and 4 Gy irRadiation + 200 mg/kg arbutin” groups, followed by the above-mentioned blood cell parameters were dropped remarkably. Conclusion: The present investigation showed that arbutin is a strong radioprotector. There were not any significant differences between the various concentrations of arbutin, however, the concentration of 50 mg/kg showed higher radioprotective effect.

Cites

No record.

References

No record.

Cite

APA: Copy

NADI, S., BANAEI, A., MOZDARANI, H., SHABESTANI MONFARED, A., ATAEI, G.R., & Abedi Firouzjah, r.. (2020). Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 18(2), 275-282. SID. https://sid.ir/paper/758654/en

Vancouver: Copy

NADI S., BANAEI A., MOZDARANI H., SHABESTANI MONFARED A., ATAEI G.R., Abedi Firouzjah r.. Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2020;18(2):275-282. Available from: https://sid.ir/paper/758654/en

IEEE: Copy

S. NADI, A. BANAEI, H. MOZDARANI, A. SHABESTANI MONFARED, G.R. ATAEI, and r. Abedi Firouzjah, “Evaluating the radioprotective effect of arbutin on mice exposed to megavoltage X-rays based on hematological parameters and lymphocytes micronucleus assay,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 18, no. 2, pp. 275–282, 2020, [Online]. Available: https://sid.ir/paper/758654/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops