Low 25(OH) Vitamin-D levels are associated with inferior graft function in living related kidney transplant recipients

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Mehrotra Sonia; SHARMA RAJESH KUMAR; GUPTA AMIT; Prasad Narayan; Bhadauria Dharmendra S.; Kaul Anupama; Patel Manas R.

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Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2018 | Volume:7 | Issue:4 Page(s): 224-229

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Title

Low 25(OH) Vitamin-D levels are associated with inferior graft function in living related kidney transplant recipients

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Keywords

Vitamin D deficiency

Estimated GFR

Kidney transplantation

Acute rejection

Abstract

Introduction: Vitamin D deficiency can impact post-transplant outcomes due to its effect on graft function and rejection. The effect of pre-and post-transplant serum vitamin D levels was evaluated on graft function. Objectives: This study aims to determine the incidence of Vitamin D deficiency and its effect on post kidney transplant allograft function in a North Indian cohort. Patients and Methods: We evaluated 57 patients on dialysis, going for transplantation. Estimated glomerular filtration rate (eGFR) was measured using modification of diet in renal disease (MDRD) formula at 2 weeks and 3, 6, 12 months interval after Kidney transplantation. Results: Pre-and post-transplant (3 months) vitamin D levels were evaluated for Vitamin D deficiency and graft function. Before transplant vitamin D levels were 25. 77 ± 13. 68 ng/mL, 40. 4% of these recipients had Vitamin D deficiency (levels <20 ng/mL). After transplant, vitamin D levels at 3 months were 22. 08 ± 11. 15 ng/mL and 54. 4% of recipients had Vitamin D deficiency. No patient was on vitamin D supplementation after transplantation. At 3 months post-transplant, recipients with vitamin D levels <20 ng/mL, had significantly lower eGFR and higher serum creatinine value as compared to the group with vitamin D levels >20ng/mL. Recipients were divided into 3 groups based on pre-and post-transplant vitamin D levels (<20, 20-30 and >30ng/mL). Pre-transplant vitamin D levels correlated with graft function at 14 days. On multiple regression analysis, 3-month post-transplant vitamin D levels correlated with 12 months eGFR. There was increased incidence of Acute rejection episodes in Vitamin D deficiency group. Conclusion: There is a high incidence of Vitamin D deficiency and insufficiency in kidney transplant recipients. Low levels of post-transplant vitamin D levels at 3 months were associated with inferior allograft function (eGFR) at 1 year.

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APA: Copy

Mehrotra, Sonia, SHARMA, RAJESH KUMAR, GUPTA, AMIT, Prasad, Narayan, Bhadauria, Dharmendra S., Kaul, Anupama, & Patel, Manas R.. (2018). Low 25(OH) Vitamin-D levels are associated with inferior graft function in living related kidney transplant recipients. JOURNAL OF RENAL INJURY PREVENTION, 7(4), 224-229. SID. https://sid.ir/paper/758982/en

Vancouver: Copy

Mehrotra Sonia, SHARMA RAJESH KUMAR, GUPTA AMIT, Prasad Narayan, Bhadauria Dharmendra S., Kaul Anupama, Patel Manas R.. Low 25(OH) Vitamin-D levels are associated with inferior graft function in living related kidney transplant recipients. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2018;7(4):224-229. Available from: https://sid.ir/paper/758982/en

IEEE: Copy

Sonia Mehrotra, RAJESH KUMAR SHARMA, AMIT GUPTA, Narayan Prasad, Dharmendra S. Bhadauria, Anupama Kaul, and Manas R. Patel, “Low 25(OH) Vitamin-D levels are associated with inferior graft function in living related kidney transplant recipients,” JOURNAL OF RENAL INJURY PREVENTION, vol. 7, no. 4, pp. 224–229, 2018, [Online]. Available: https://sid.ir/paper/758982/en

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