URINARY BETA 2 MICROGLOBULIN IN VARIOUS GRADES OF RENAL SCAR IN PYELONEPHRITIS IN CHILDREN

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SHARIFIAN M.; ANVARIPOUR N.; KARIMI A.

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Journal: Iranian Journal of Pediatrics Year:2006 | Volume:16 | Issue:3 Page(s): 277-282

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Title

URINARY BETA 2 MICROGLOBULIN IN VARIOUS GRADES OF RENAL SCAR IN PYELONEPHRITIS IN CHILDREN

Author(s)

SHARIFIAN M. | ANVARIPOUR N. | KARIMI A. | Issue Writer Certificate

Keywords

BETA 2 MICROGLOBULINQ4

RENAL SCARQ3

PYELONEPHRITIS CHILDRENQ3

VESICO-URETERAL REFLUXQ3

Abstract

Background: For patients who have renal involvement during urinary infection or children with VESICO-URETERAL REFLUX (VUR), renal Dimercaptosuccinic Acid (DMSA) scan is performed which exposes children to significant radiation. β²MG is a low molecular weight protein freely filtered by the glomeruli and then actively reabsorbed normally up to 99.9% in the proximal tubules; its urinary measurement is a good index of proximal tubular function of these cells as a primary screening test.Methods: Urinary ß²MG/Cr was measured in random urine samples in 53 pyelonephritis patients. Urine samples were obtained at the time of Voiding Cysto-Ureterography (VCUG). DMSA renal scan was performed in all patients. ß²MG and urine creatinine were tested by ELISA and auto analyzer, respectively.Findings: Twenty children had various grades of RENAL SCAR. Results were compared with ratios of 19 children with low uptake scanning and with 14 normal scanning. The mean urinary ß²MG/Cr was higher in the scarring group (5.23±10.6) than in the normal group (0.19±0.2) and in low uptake group (0.49±0.86). Patients with grade 3 had higher values (14.69± 15.82) than grades 1 (0.36± 0.35) and 2 (3.37± 5.2). Patients without RENAL SCAR had ß²MG/Cr ratio below 0.46 microgram/mg. The mean β2MG was higher in the VUR group (3/45± 7.97) than non-VUR group (0.23 ± 0.24) ug/mgCr (P= 0.01). The mean β2MG/Cr was higher in patients with VUR grades 4 and 5 (8.93±12.01) than patients with VUR grades 1 to 3 (0.81± 3.04) (P= 0.02).Conclusion: This study revealed that the maximum B2MG/Cr value in non-VUR children was 0.85 microgram/mgCr, higher values can be considered as a cut off point in screening children for VUR. Measurement of Urinary B2MG may be useful in the early detection of tubular damage in VUR patients and patients with RENAL SCARs.

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APA: Copy

SHARIFIAN, M., ANVARIPOUR, N., & KARIMI, A.. (2006). URINARY BETA 2 MICROGLOBULIN IN VARIOUS GRADES OF RENAL SCAR IN PYELONEPHRITIS IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 16(3), 277-282. SID. https://sid.ir/paper/75906/en

Vancouver: Copy

SHARIFIAN M., ANVARIPOUR N., KARIMI A.. URINARY BETA 2 MICROGLOBULIN IN VARIOUS GRADES OF RENAL SCAR IN PYELONEPHRITIS IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2006;16(3):277-282. Available from: https://sid.ir/paper/75906/en

IEEE: Copy

M. SHARIFIAN, N. ANVARIPOUR, and A. KARIMI, “URINARY BETA 2 MICROGLOBULIN IN VARIOUS GRADES OF RENAL SCAR IN PYELONEPHRITIS IN CHILDREN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 16, no. 3, pp. 277–282, 2006, [Online]. Available: https://sid.ir/paper/75906/en

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