STUDY OF ANTIEPILEPTIC DRUGS EFFECTS ON BONE METABOLISM

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ASHRAFI M.R.; KHOSHHAL DEHDAR F.; RABANI ALI; SALAJEGHEH N.; MOHAMMADIAN NASAB A.; SHAMS S.; HAGHI ASHTIANI M.T.; SOTOUDEH A.

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Journal: Iranian Journal of Pediatrics Year:2005 | Volume:15 | Issue:4 Page(s): 347-352

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Title

STUDY OF ANTIEPILEPTIC DRUGS EFFECTS ON BONE METABOLISM

Author(s)

Keywords

ANTIEPILEPTIC DRUGSQ3

BONE METABOLISMQ3

ALKALINE PHOSPHATESQ4

PTHQ2

Abstract

Background: There are numerous reports about the adverse effects of ANTIEPILEPTIC DRUGS (AED) on BONE METABOLISM. This study was designed to evaluate these effects in children and adolescents. Methods: We compared BONE METABOLISM in children and adolescences 4-15 years old who were treated for 6 month with AED compare with a control group at the same age. BONE METABOLISM was evaluated by measurement of serum calcium, phosphorus, ALKALINE PHOSPHATES (ALP) and parathormone (PTH) in both group. Findings: 119 patients and 119 controls were studied during a 20 months period. Normal serum calcium and phosphorus levels were observed in 96.6% and 93.3% of cases respectively. Serum alkaline phosphatase was normal in 76.5% of patients while raised levels were observed in the remaining 23.5%. PTH was normal in 77.3% of patients and increased in 18.5 % of cases. Serum ALP and PTH level were significantly higher than control group (P=0.00). Highest ALP and PTH levels were seen in carbamazepine consumers while patients on sodium valproate showed the least rise. Conclusions: Periodic measurements of calcium, phosphorus, ALP, and specially PTH is recommended for the evaluation of BONE METABOLISM in long-term treatment with AED, including sodium valproate.

Cites

ANTIEPILEPTIC DRUGS EFFECT ON VITAMIN D STATUS OF EPILEPTIC CHILDREN

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APA: Copy

ASHRAFI, M.R., KHOSHHAL DEHDAR, F., RABANI, ALI, SALAJEGHEH, N., MOHAMMADIAN NASAB, A., SHAMS, S., HAGHI ASHTIANI, M.T., & SOTOUDEH, A.. (2005). STUDY OF ANTIEPILEPTIC DRUGS EFFECTS ON BONE METABOLISM. IRANIAN JOURNAL OF PEDIATRICS, 15(4), 347-352. SID. https://sid.ir/paper/75922/en

Vancouver: Copy

ASHRAFI M.R., KHOSHHAL DEHDAR F., RABANI ALI, SALAJEGHEH N., MOHAMMADIAN NASAB A., SHAMS S., HAGHI ASHTIANI M.T., SOTOUDEH A.. STUDY OF ANTIEPILEPTIC DRUGS EFFECTS ON BONE METABOLISM. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2005;15(4):347-352. Available from: https://sid.ir/paper/75922/en

IEEE: Copy

M.R. ASHRAFI, F. KHOSHHAL DEHDAR, ALI RABANI, N. SALAJEGHEH, A. MOHAMMADIAN NASAB, S. SHAMS, M.T. HAGHI ASHTIANI, and A. SOTOUDEH, “STUDY OF ANTIEPILEPTIC DRUGS EFFECTS ON BONE METABOLISM,” IRANIAN JOURNAL OF PEDIATRICS, vol. 15, no. 4, pp. 347–352, 2005, [Online]. Available: https://sid.ir/paper/75922/en

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