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Information Journal Paper

Title

Status of FAS and FAS Ligand Gene Polymorphisms in Patients with Breast Cancer in Northeastern IRAN

Pages

  23-29

Abstract

 Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and Metastasis. Gene polymorphisms including-1377 G/A in the promoter region of FAS and-844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evaluated association of these polymorphisms with risk of Metastasis of Breast cancer, in a population selected from Mashhad, Iran. A total of 115 patients with Breast cancer and 115 controls were recruited in this case-control study. Polymerase Chain Reaction-based Restriction Fragment Length Polymorphism (PCR-RFLP) was applied for genotyping on extracted DNA from participant’ s blood. Unconditional logistic regression was used to estimate cancer risk by calculating odds ratios (OR) and their 95% confidence intervals (95% CIs). Results: There was no significant association between these genetic polymorphisms and Breast cancer risk. Additionally, our results showed no significant influence from the above mentioned Gene polymorphisms on Metastasis of Breast cancer. Conclusions: These results suggest that the FAS-1377G/A and FASL-844 C/T Gene polymorphism don’ t have much influence on the susceptibility to Metastasis of Breast cancer in northeastern Iranian population. Therefore, we suggest to investigate impact of other candidate Gene polymorphisms on Metastasis of Breast cancer for future research.

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    APA: Copy

    JALALI, SEYED AMIR, HOMAEI SHANDIZ, FATEMEH, TAVAKOL AFSHARI, JALIL, Davarpanah Tanha Ghochan, Maryam, NIKPOOR, AMIN REZA, & MOHAMMADI, MOJGAN. (2018). Status of FAS and FAS Ligand Gene Polymorphisms in Patients with Breast Cancer in Northeastern IRAN. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 7(1), 23-29. SID. https://sid.ir/paper/759695/en

    Vancouver: Copy

    JALALI SEYED AMIR, HOMAEI SHANDIZ FATEMEH, TAVAKOL AFSHARI JALIL, Davarpanah Tanha Ghochan Maryam, NIKPOOR AMIN REZA, MOHAMMADI MOJGAN. Status of FAS and FAS Ligand Gene Polymorphisms in Patients with Breast Cancer in Northeastern IRAN. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2018;7(1):23-29. Available from: https://sid.ir/paper/759695/en

    IEEE: Copy

    SEYED AMIR JALALI, FATEMEH HOMAEI SHANDIZ, JALIL TAVAKOL AFSHARI, Maryam Davarpanah Tanha Ghochan, AMIN REZA NIKPOOR, and MOJGAN MOHAMMADI, “Status of FAS and FAS Ligand Gene Polymorphisms in Patients with Breast Cancer in Northeastern IRAN,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 7, no. 1, pp. 23–29, 2018, [Online]. Available: https://sid.ir/paper/759695/en

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