Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects

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KALANTARI KHANDANI BEHJAT; SHAFIEIPOUR SARA; Mobasserfar Amir; ZAHEDI MOHAMMAD JAVAD; HASHEMI MOHAMMAD; HAYATBAKHSH ABBASI MOHAMMAD MAHDI; Darvish Moghadam Sodaif

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Journal: Journal of Kerman University of Medical Sciences Year:2020 | Volume:27 | Issue:3 Page(s): 204-212

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Title

Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects

Author(s)

Keywords

Rs3746444

Polymorphism

miR 499

Colon Cancer

Abstract

Background: Single nucleotide Polymorphisms (SNPs) have been introduced as a new genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the Rs3746444 Polymorphism of miR-499 in patients with Colon Cancer in comparison with healthy subjects. Methods: This case-control study was conducted to investigate Rs3746444 Polymorphism of miR-499 in blood samples of case and control groups. Patients with a confirmed diagnosis of cancer based on pathologic report were enrolled in the study as the case group and compared with healthy subjects. The level of significance was considered at p< 0. 05. Result: The mean of DNA count in samples was 63. 17± 23. 51 that was significantly higher in the case group. The Rs3746444 Polymorphism of miR-499 was significantly higher in patients with cancer compared to the healthy subjects (P < 0. 05). Conclusion: In this study, Rs3746444 Polymorphism of miR-499 was significantly higher in patients with Colon Cancer, which indicated that people with this Polymorphism had a higher risk for malignancy.

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APA: Copy

KALANTARI KHANDANI, BEHJAT, SHAFIEIPOUR, SARA, Mobasserfar, Amir, ZAHEDI, MOHAMMAD JAVAD, HASHEMI, MOHAMMAD, HAYATBAKHSH ABBASI, MOHAMMAD MAHDI, & Darvish Moghadam, Sodaif. (2020). Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 27(3), 204-212. SID. https://sid.ir/paper/759759/en

Vancouver: Copy

KALANTARI KHANDANI BEHJAT, SHAFIEIPOUR SARA, Mobasserfar Amir, ZAHEDI MOHAMMAD JAVAD, HASHEMI MOHAMMAD, HAYATBAKHSH ABBASI MOHAMMAD MAHDI, Darvish Moghadam Sodaif. Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(3):204-212. Available from: https://sid.ir/paper/759759/en

IEEE: Copy

BEHJAT KALANTARI KHANDANI, SARA SHAFIEIPOUR, Amir Mobasserfar, MOHAMMAD JAVAD ZAHEDI, MOHAMMAD HASHEMI, MOHAMMAD MAHDI HAYATBAKHSH ABBASI, and Sodaif Darvish Moghadam, “Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 3, pp. 204–212, 2020, [Online]. Available: https://sid.ir/paper/759759/en

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