Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model

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Elsurer C.; Celik Z.E.; YAVAS G.; YAVAS C.

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Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2020 | Volume:18 | Issue:1 Page(s): 149-155

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Title

Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model

Author(s)

Elsurer C. | Celik Z.E. | YAVAS G. | YAVAS C. | Issue Writer Certificate

Keywords

Inflammation

fibrosis

salivary gland

submandibular gland

radiotherapy

rat

Abstract

pre-radiation treatment with a mineralocorticoid receptor (MR) antagonist, spironolactone (S), may have radioprotective effect on salivary glands. Materials and Methods: Study included 30 adult female Wistar albino rats. rats were divided into four groups (G); G1, control group; G2, RT-only group, G3, S-only group; G4, RT plus S group. rats were sacrificed at 6th hour; 21st and 100th days after RT. salivary gland samples were taken for microscopical examination. Results: Periductal-perivascular Inflammation scores in 21st and 100th days tended to be higher in G2 than in G4, but the difference was not statistically significant. Periductal-perivascular fibrosis score was significantly different between the groups in 100th day (P: 0. 010). Pairwise comparisons revealed that periductal-perivascular fibrosis scores were different between G1 and G2 (P: 0. 014), G2 and G3 (P: 0. 014), G2 and G4 (P: 0. 034). Conclusions: MR blockade with S, when initiated before RT, ameliorates late radiation-induced fibrosis in the submandibular glands.

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APA: Copy

Elsurer, C., Celik, Z.E., YAVAS, G., & YAVAS, C.. (2020). Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 18(1), 149-155. SID. https://sid.ir/paper/759826/en

Vancouver: Copy

Elsurer C., Celik Z.E., YAVAS G., YAVAS C.. Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2020;18(1):149-155. Available from: https://sid.ir/paper/759826/en

IEEE: Copy

C. Elsurer, Z.E. Celik, G. YAVAS, and C. YAVAS, “Spironolactone ameliorates the radiation-induced late fibrosis in salivary glands in a rat model,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 18, no. 1, pp. 149–155, 2020, [Online]. Available: https://sid.ir/paper/759826/en

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